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Synaptotagmin V (SYT5) (AA 15-110) antibody

Details for Product No. ABIN968801, Supplier: Log in to see
Antigen
  • CG13462
  • CG3020
  • CG42333
  • Dmel\\CG42333
  • Dmel_CG13462
  • Dmel_CG3020
  • Syt V
  • Syt beta
  • Syt13
  • SytV
  • dsytbeta
  • syt13
  • sytbeta
  • syt5
  • zgc:92682
  • ARABIDOPSIS THALIANA SYNAPTOTAGMIN HOMOLOG E
  • ATSYTE
  • NTMC2TYPE2.1
  • SYNAPTOTAGMIN HOMOLOG E
  • SYT5
  • SYTE
  • T25N20.15
  • synaptotagmin 5
  • Sytv
  • SytIX
Epitope
AA 15-110
16
15
11
3
2
2
1
Reactivity
Mouse (Murine), Rat (Rattus)
37
6
3
2
2
2
1
Host
Mouse
27
11
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
3
3
3
3
3
3
1
Application
Western Blotting (WB)
35
26
5
1
1
Supplier
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Immunogen Rat Synaptotagmin V aa. 15-110
Clone 46-Synaptotagmin V
Isotype IgG1
Cross-Reactivity Mouse (Murine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Synaptotagmin V (SYT5 Antibody Abstract)
Background Synaptotagmin I belongs to a family of C2 domain containing proteins, which include Synatotagmin II to XI and Srg1. All of the members of this protein family contain a single transmembrane region and two copies of an internal repeat that is homologous to the regulatory region of Protein Kinase C (C2A and C2B domains). Synaptotagmin I-V and IX-XI are found in brain, while synaptotagmin VI-VIII are found in non-neuronal tissues. Synaptotagmin I and II have regulatory roles in synaptic vesicle docking and fusion with the plasmalemma. Both synaptotagmin I and II act as vSNAREs that form a complex with SNAP-25 and syntaxin at the plasma membrane. This complex is required for rapid, calcium-dependent synaptic vesicle exocytosis. In addition to their roles in exocytosis, synaptotagmin I and II can bind to calcium channels, calmodulin, and the clathrin adaptor protein AP-2. Synatotagmins III, V, VI, and X cannot bind IP4 like other synaptotagmins, but like most synaptotagmins these family members form heteromers with other synaptotagmins. Synaptotagmins IV, X, and Srg1 may regulate vesicular trafficking during brain development and plasticity. In neuronal and non-neuronal tissues, synaptotagmins may be important for vesicle exocytosis, endocytosis, and trafficking, as well calcium signaling.
Molecular Weight 48 kDa
Research Area Cancer
Pathways
Comment

Related Products: ABIN968545, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.
Supplier Images
Western Blotting (WB) image for anti-Synaptotagmin V (SYT5) (AA 15-110) antibody (ABIN968801) Western blot analysis of Synaptotagmin V on rat cerebrum lysate. Lane 1: 1:1000, lane...
Product cited in: Marquèze, Berton, Seagar: "Synaptotagmins in membrane traffic: which vesicles do the tagmins tag?" in: Biochimie, Vol. 82, Issue 5, pp. 409-20, 2000 (PubMed).

Craxton, Goedert: "Synaptotagmin V: a novel synaptotagmin isoform expressed in rat brain." in: FEBS letters, Vol. 361, Issue 2-3, pp. 196-200, 1995 (PubMed).

Hudson, Birnbaum: "Identification of a nonneuronal isoform of synaptotagmin." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 13, pp. 5895-9, 1995 (PubMed).