Synaptotagmin V (SYT5) (AA 15-110) antibody

Antigen: Synaptotagmin V (SYT5)

Synonyms: CG13462, CG3020, CG42333, DmelCG42333, dsytbeta, Syt beta, Syt V, sytbeta, SytV, SytIX, MGC105442, Sytv, syt5, MGC173836, zgc:92682, MGC151577, ARABIDOPSIS THALIANA SYNAPTOTAGMIN HOMOLOG E, ATSYTE, NTMC2T2.1, NTMC2TYPE2.1, synaptotagmin 5, SYNAPTOTAGMIN HOMOLOG E, SYT5, SYTE, T25N20.15

Binding Site: AA 15-110

Clonality: Monoclonal (46)

Host: Mouse

Reactivity: Rat (Rattus)

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Catalog no.: ABIN968801

Additional Information

Alternative name: Synaptotagmin V

Immunogen: Rat Synaptotagmin V

Cross-Reactivity: Mouse (Murine)

Format: Liquid

Isotype: IgG1

Clone: 46

Description: Synaptotagmin I belongs to a family of C2 domain containing proteins, which include Synatotagmin II to XI and Srg1. All of the members of this protein family contain a single transmembrane region and two copies of an internal repeat that is homologous to the regulatory region of Protein Kinase C (C2A and C2B domains). Synaptotagmin I-V and IX-XI are found in brain, while synaptotagmin VI-VIII are found in non-neuronal tissues. Synaptotagmin I and II have regulatory roles in synaptic vesicle docking and fusion with the plasmalemma. Both synaptotagmin I and II act as vSNAREs that form a complex with SNAP-25 and syntaxin at the plasma membrane. This complex is required for rapid, calcium-dependent synaptic vesicle exocytosis. In addition to their roles in exocytosis, synaptotagmin I and II can bind to calcium channels, calmodulin, and the clathrin adaptor protein AP-2. Synatotagmins III, V, VI, and X cannot bind IP4 like other synaptotagmins, but like most synaptotagmins these family members form heteromers with other synaptotagmins. Synaptotagmins IV, X, and Srg1 may regulate vesicular trafficking during brain development and plasticity. In neuronal and non-neuronal tissues, synaptotagmins may be important for vesicle exocytosis, endocytosis, and trafficking, as well calcium signaling.

Characteristics: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Molecular Weight: 48 kDa

Comments:

Related Products: ABIN968545, ABIN967389

Synonyms: CG13462, CG3020, CG42333, DmelCG42333, dsytbeta, Syt beta, Syt V, sytbeta, SytV, SytIX, MGC105442, Sytv, syt5, MGC173836, zgc:92682, MGC151577, ARABIDOPSIS THALIANA SYNAPTOTAGMIN HOMOLOG E, ATSYTE, NTMC2T2.1, NTMC2TYPE2.1, synaptotagmin 5, SYNAPTOTAGMIN HOMOLOG E, SYT5, SYTE, T25N20.15

Application Details

Concentration: 250 µg/ml

Purity: Purified

Purification: Purified from tissue culture supernatant or ascites by affinity chromatography.

Buffer: Aqueous buffered solution containing BSA, glycerol.

Preservative: 0.09% Sodium azide.

Storage: Store undiluted at -20° C.

Research Area: Cancer

Restrictions: For Research Use only

Images

Western blot analysis of Synaptotagmin V on rat cerebrum lysate. Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of anti-Synaptotagmin V antibody.

Publications

Product: Hudson, Birnbaum: "Identification of a nonneuronal isoform of synaptotagmin." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 13, pp. 5895-9, 1995 (PubMed).

Craxton, Goedert: "Synaptotagmin V: a novel synaptotagmin isoform expressed in rat brain." in: FEBS letters, Vol. 361, Issue 2-3, pp. 196-200, 1995 (PubMed).

Marquèze, Berton, Seagar: "Synaptotagmins in membrane traffic: which vesicles do the tagmins tag?" in: Biochimie, Vol. 82, Issue 5, pp. 409-20, 2000 (PubMed).