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BMPR2 antibody (AA 803-996)

BMPR2 Reactivity: Human, Mouse, Rat WB, IF Host: Mouse Monoclonal 18-BMPR unconjugated
Catalog No. ABIN968806
  • Target See all BMPR2 Antibodies
    BMPR2 (Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2))
    Binding Specificity
    • 17
    • 16
    • 15
    • 8
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 803-996
    Reactivity
    • 70
    • 43
    • 16
    • 3
    • 1
    Human, Mouse, Rat
    Host
    • 64
    • 6
    • 1
    Mouse
    Clonality
    • 65
    • 6
    Monoclonal
    Conjugate
    • 34
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This BMPR2 antibody is un-conjugated
    Application
    • 54
    • 35
    • 28
    • 22
    • 13
    • 13
    • 13
    • 10
    • 8
    • 4
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Cross-Reactivity
    Human, Rat (Rattus)
    Characteristics
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Mouse BMPR-II aa. 803-996
    Clone
    18-BMPR
    Isotype
    IgG1
    Top Product
    Discover our top product BMPR2 Primary Antibody
  • Comment

    Related Products: ABIN968540, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store undiluted at -20°C.
  • Regazzoni, Winterhalter, Rohrer: "Type I collagen induces expression of bone morphogenetic protein receptor type II." in: Biochemical and biophysical research communications, Vol. 283, Issue 2, pp. 316-22, (2001) (PubMed).

    , Lane, Machado, Pauciulo, Thomson, Phillips, Loyd, Nichols, Trembath: "Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension." in: Nature genetics, Vol. 26, Issue 1, pp. 81-4, (2000) (PubMed).

    Rosenzweig, Imamura, Okadome, Cox, Yamashita, ten Dijke, Heldin, Miyazono: "Cloning and characterization of a human type II receptor for bone morphogenetic proteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 17, pp. 7632-6, (1995) (PubMed).

  • Target
    BMPR2 (Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2))
    Alternative Name
    BMPR-II (BMPR2 Products)
    Synonyms
    BMPR-II antibody, BMPR3 antibody, BMR2 antibody, BRK-3 antibody, PPH1 antibody, T-ALK antibody, 2610024H22Rik antibody, AL117858 antibody, AW546137 antibody, BB189135 antibody, BMP-2 antibody, BMPR-2 antibody, BMPRII antibody, Gm20272 antibody, Bmpr-II antibody, bmprii antibody, bone morphogenetic protein receptor type 2 antibody, bone morphogenetic protein receptor, type II b (serine/threonine kinase) antibody, bone morphogenetic protein receptor, type II (serine/threonine kinase) antibody, BMPR2 antibody, bmpr2b antibody, Bmpr2 antibody
    Background
    The transforming growth factor beta (TGFbeta)/activin/BMP family of growth factor plays a diverse and important role in growth, development, and differentiation. The receptors for this famiy of proteins are type I and II ser/thr kinase receptors. Bone morphogenetic protein receptors (BMPRs) include two type I receptors, BMPR-IA and BMPR-IB, and a type II receptor, BMPR-II. BMPR-II is a widely expressed receptor, with high mRNA expression during development in many tissues. BMPR-II transfected COS-1 cells show binding to BMP-7 (osteogenic protein-1) and BMP-4, and co-transfection with the type I receptor, ActR-I, leads to transcriptional activation in response to BMP-7. In addition, extracellular matrix proteins may regulate the expression of BMPR-II during angiogenesis, since fibrillar type I collagen induces BMPR-II expression in endothelial cells. In familial primary pulmonary hypertension, the BMPR-II gene is mutated in a manner that may disrupt ligand binding, kinase activity, and heteromeric dimer formation. Thus, BMPR-II may be an important mediator of BMP effects during growth and differentiation of endothelial cells.
    Molecular Weight
    130 kDa
    Pathways
    Growth Factor Binding
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