You are viewing an incomplete version of our website. Please click to reload the website as full version.

Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1) (AA 1-94) antibody

Details for Product No. ABIN968820, Supplier: Login to see New
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Synonyms Xp35.1, cdk5r1, p35, zgc:92814, CDK5R1, CDK5P35, CDK5R, NCK5A, p23, p25, p35nck5a, Cdk5r, D11Bwg0379e, P25/P35, 1110014C03Rik, Tmp21, p24delta1, PCHK23, TCTP
AA 1-94
(20), (18), (17), (14), (14), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Mouse (Murine), Rat (Rattus)
(93), (46), (25), (20), (18), (18), (18), (2), (2)
(68), (25), (1)
Clonality (Clone)
Monoclonal ()
(6), (6), (6), (5), (5), (5), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunofluorescence (IF), Western Blotting (WB)
(62), (60), (54), (28), (21), (20), (11), (5)
Pubmed 4 references available
Supplier Login to see New
Catalog number from supplier Login to see New
Quantity 50 μg
Shipping to United States ( )
Immunogen Mouse p23 aa. 1-94
Clone 16-p23
Isotype IgG1
Cross-Reactivity Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name p23 (CDK5R1 Antibody Abstract)
Background Molecular chaperones are a diverse group of proteins that modulate polypeptide stability through a process of ATP hydrolysis and the interaction with exposed hydrophobic residues on substrate proteins. Members of the heat shock protein (Hsp) group of chaperones were so named because their expression is rapidly induced upon heat shock or stress. Hsp90 and Hsp70 form complexes with chaperone accessory factors, such as TCP-1, Hsp104, HiP, immunophilins (FKBP52 and FKBP51), HOP, Hsp40, Bag-1, and p23. A complex of Hsp90, Hsp70, p48, Cyp-40, and p60 is known as the steroid aporeceptor complex that maintains a high affinity binding site in unbound intracellular hormone receptors. p23 is a widely expressed chaperone-associated protein that interacts with the ligand-bound steroid holoreceptor complex, and regulates holoreceptor-mediated transcriptional activity. In addition, p23/Hsp90 complexes may regulate telomerase complex assembly, and remain associated with the active telomerase holoenzyme. Thus, p23 is a chaperone accessory factor involved in the assembly of protein complexes, such as steroid hormone receptor and telomerase complexes.
Molecular Weight 23 kDa
Research Area Cancer, Metabolism

Related Products: ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.
Supplier Images
Western Blotting (WB) image for anti-Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1) (AA 1-94) antibody (ABIN968820) Western blot analysis of p23 on a mouse testis lysate. Lane 1: 1:1000, lane 2: 1:2000...
Immunofluorescence (IF) image for anti-Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1) (AA 1-94) antibody (ABIN968820) Immunofluorescence staining of normal rat kidney cells.
Western Blotting (WB) image for anti-Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1) (AA 1-94) antibody (ABIN968820) anti-Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1) (AA 1-94) antibody (Image 3)
Product cited in: Forsythe, Jarvis, Turner et al.: "Stable association of hsp90 and p23, but Not hsp70, with active human telomerase." in: The Journal of biological chemistry, Vol. 276, Issue 19, pp. 15571-4, 2001 (PubMed).

Freeman, Felts, Toft et al.: "The p23 molecular chaperones act at a late step in intracellular receptor action to differentially affect ligand efficacies." in: Genes & development, Vol. 14, Issue 4, pp. 422-34, 2000 (PubMed).

Freeman, Toft, Morimoto: "Molecular chaperone machines: chaperone activities of the cyclophilin Cyp-40 and the steroid aporeceptor-associated protein p23." in: Science (New York, N.Y.), Vol. 274, Issue 5293, pp. 1718-20, 1997 (PubMed).

Johnson, Beito, Krco et al.: "Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes." in: Molecular and cellular biology, Vol. 14, Issue 3, pp. 1956-63, 1994 (PubMed).

Catalog No. ABIN968820
Contact our Customer Service for availability and price in your country.

Order hotline:

  • +1 877 302 8632
  • +1 888 205 9894 (TF)