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CDK5R1 antibody (Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35)) (AA 1-94)

Details for Product anti-CDK5R1 Antibody No. ABIN968820, Supplier: Log in to see
Antigen
  • Xp35.1
  • cdk5r1
  • p35
  • zgc:92814
  • CDK5R1
  • CDK5P35
  • CDK5R
  • NCK5A
  • p23
  • p25
  • p35nck5a
  • Cdk5r
  • D11Bwg0379e
  • P25/P35
  • 1110014C03Rik
  • Tmp21
  • p24delta1
  • PCHK23
  • TCTP
  • cyclin-dependent kinase 5, regulatory subunit 1 (p35)
  • cyclin-dependent kinase 5, regulatory subunit 1b (p35)
  • related RAS viral (r-ras) oncogene homolog
  • S100 calcium binding protein A9
  • transmembrane emp24-like trafficking protein 10 (yeast)
  • tumor protein, translationally-controlled 1
  • cdk5r1-a
  • cdk5r1b
  • CDK5R1
  • Cdk5r1
  • Rras
  • S100A9
  • Tmed10
  • TPT1
Alternatives
anti-Mouse (Murine) CDK5R1 antibody for Immunofluorescence
Epitope
AA 1-94
20
16
14
12
3
2
2
1
1
1
1
1
1
1
1
Reactivity
Mouse (Murine), Rat (Rattus)
100
57
34
21
21
19
19
6
3
2
2
2
1
1
Host
Mouse
74
26
1
Clonality (Clone)
Monoclonal ()
Conjugate
This CDK5R1 antibody is un-conjugated
6
6
6
5
5
5
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
67
62
59
33
22
22
18
13
6
1
1
Options
Supplier
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Immunogen Mouse p23 aa. 1-94
Clone 16-p23
Isotype IgG1
Cross-Reactivity Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name p23 (CDK5R1 Antibody Abstract)
Background Molecular chaperones are a diverse group of proteins that modulate polypeptide stability through a process of ATP hydrolysis and the interaction with exposed hydrophobic residues on substrate proteins. Members of the heat shock protein (Hsp) group of chaperones were so named because their expression is rapidly induced upon heat shock or stress. Hsp90 and Hsp70 form complexes with chaperone accessory factors, such as TCP-1, Hsp104, HiP, immunophilins (FKBP52 and FKBP51), HOP, Hsp40, Bag-1, and p23. A complex of Hsp90, Hsp70, p48, Cyp-40, and p60 is known as the steroid aporeceptor complex that maintains a high affinity binding site in unbound intracellular hormone receptors. p23 is a widely expressed chaperone-associated protein that interacts with the ligand-bound steroid holoreceptor complex, and regulates holoreceptor-mediated transcriptional activity. In addition, p23/Hsp90 complexes may regulate telomerase complex assembly, and remain associated with the active telomerase holoenzyme. Thus, p23 is a chaperone accessory factor involved in the assembly of protein complexes, such as steroid hormone receptor and telomerase complexes.
Molecular Weight 23 kDa
Research Area Cancer, Metabolism
Pathways Stem Cell Maintenance
Comment

Related Products: ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.
Supplier Images
Western Blotting (WB) image for anti-CDK5R1 antibody (Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35)) (AA 1-94) (ABIN968820) Western blot analysis of p23 on a mouse testis lysate. Lane 1: 1:1000, lane 2: 1:2000...
Immunofluorescence (IF) image for anti-CDK5R1 antibody (Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35)) (AA 1-94) (ABIN968820) Immunofluorescence staining of normal rat kidney cells.
Western Blotting (WB) image for anti-CDK5R1 antibody (Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35)) (AA 1-94) (ABIN968820) anti-Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1) (AA 1-94) antibody (Image 3)
Product cited in: Forsythe, Jarvis, Turner, Elmore, Holt: "Stable association of hsp90 and p23, but Not hsp70, with active human telomerase." in: The Journal of biological chemistry, Vol. 276, Issue 19, pp. 15571-4, 2001 (PubMed).

Freeman, Felts, Toft, Yamamoto: "The p23 molecular chaperones act at a late step in intracellular receptor action to differentially affect ligand efficacies." in: Genes & development, Vol. 14, Issue 4, pp. 422-34, 2000 (PubMed).

Freeman, Toft, Morimoto: "Molecular chaperone machines: chaperone activities of the cyclophilin Cyp-40 and the steroid aporeceptor-associated protein p23." in: Science (New York, N.Y.), Vol. 274, Issue 5293, pp. 1718-20, 1997 (PubMed).

Johnson, Beito, Krco, Toft: "Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes." in: Molecular and cellular biology, Vol. 14, Issue 3, pp. 1956-63, 1994 (PubMed).