Receptor-Interacting Serine-threonine Kinase 2 (RIPK2) (AA 333-532) antibody

Details for Product No. ABIN968829
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Synonyms 2210420D18Rik, CARD3, CARDIAK, CCK, D4Bwg0615e, RICK, RIP2, GIG30, RIPK2
AA 333-532
(14), (13), (13), (5), (5), (3), (2), (2), (1), (1), (1), (1)
(101), (42), (22), (1), (1), (1)
(83), (14), (5)
Clonality (Clone)
Monoclonal ()
Western Blotting (WB), Immunofluorescence (IF)
(98), (51), (28), (24), (10), (7), (3), (2), (1), (1), (1)
Pubmed 4 references available
Catalog no. ABIN968829
Quantity 150 µg
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Immunogen Human RIP2/RICK
Clone 25
Isotype IgG1
Cross-Reactivity Dog (Canine), Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name RIP2/RICK
Background Members of the TNFR family (TNFRs, DRs, Fas, lymphotoxin-beta-receptor, CD40, CD30, and OX-40) regulate a variety of cellular responses, such as cell activation, proliferation, differentiation, NF-kappaB activation, and apoptosis. Signaling through TNFR family members involves several families of receptor-associated proteins. RIP and RIP2 (RICK/Cardiak) are ser/thr kinase adaptor molecules that associate with TNFR complexes. Both RIPs contain homologous N-teriminal ser/thr kinase domains, but RIP contains a C-terminal death domain, while RIP2 contains a C-terminal caspase activation and recruitment domain (CARD) similar to those found in IAPs. Both RIP and RIP2 can activate NF-kappaB and cause cell death. RIP2 is recruited to TNFRs through interactions with TRAF1, TRAF5, and TRAF6, and RIP2 activation of NF-kappaB requires IKKalpha, IKKbeta, and IKKgamma. In addition, RIP2 can be activated through interactions with Ras-activated Raf1, and RIP2 can activate ERK1 and ERK2. Thus, RIP proteins may regulate TNFR signaling through both ser/thr kinase activity and interaction with the apoptotic machinery.
Molecular Weight 61 kDa

Related Products: ABIN968536, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Supplier Images
anti-Receptor-Interacting Serine-threonine Kinase 2 (RIPK2) (AA 333-532) antibody Western blot analysis of RIP2/RICK on human endothelial cell lysate. Lane 1: 1:500, lane 2: 1:1000, lane 3: 1:2000 dilution of anti-RIP2/RICK.
anti-Receptor-Interacting Serine-threonine Kinase 2 (RIPK2) (AA 333-532) antibody (2) Immunofluorescent staining of HeLa cells.
Product cited in: Inohara, del Peso, Koseki et al.: "RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis." in: The Journal of biological chemistry, Vol. 273, Issue 20, pp. 12296-300, 1998 (PubMed).

McCarthy, Ni, Dixit: "RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase." in: The Journal of biological chemistry, Vol. 273, Issue 27, pp. 16968-75, 1998 (PubMed).

Navas, Baldwin, Stewart: "RIP2 is a Raf1-activated mitogen-activated protein kinase kinase." in: The Journal of biological chemistry, Vol. 274, Issue 47, pp. 33684-90, 1999 (PubMed).

Inohara, Koseki, Lin et al.: "An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways." in: The Journal of biological chemistry, Vol. 275, Issue 36, pp. 27823-31, 2000 (PubMed).

Hosts (83), (14), (5)
Reactivities (101), (42), (22), (1), (1), (1)
Applications (98), (51), (28), (24), (10), (7), (3), (2), (1), (1), (1)
Epitopes (14), (13), (13), (5), (5), (3), (2), (2), (1), (1), (1), (1)
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