AZGP1 antibody (alpha-2-Glycoprotein 1, Zinc-Binding) (AA 7-102)

Details for Product anti-AZGP1 Antibody No. ABIN968832, Supplier: Log in to see
Antigen
  • Zag
  • ZA2G
  • ZAG
  • ZA2GA
  • Zna2gp
  • alpha-2-glycoprotein 1, zinc
  • alpha-2-glycoprotein 1, zinc-binding
  • Azgp1
  • AZGP1
Alternatives
anti-Human AZGP1 antibody for ELISA
Epitope
AA 7-102
10
7
6
5
5
3
3
3
2
2
2
1
1
Reactivity
Human
65
11
11
3
1
Host
Mouse
64
7
4
2
Clonality (Clone)
Monoclonal ()
Conjugate
This AZGP1 antibody is un-conjugated
7
4
Application
Western Blotting (WB)
72
42
20
7
5
4
4
4
1
1
1
1
1
1
Options
Supplier
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Immunogen Human Zn-alpha2-glycoprotein aa. 7-102
Clone 35-Zn-alpha2
Isotype IgG1
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Zn-alpha 2-glycoprotein (AZGP1 Antibody Abstract)
Background Zn-alpha2-glycoprotein (ZAG) is a soluble protein that was originally isolated from human plasma. ZAG is related to class I major histocompatibility complex (MHC) proteins, which are involved in peptide presentation to cytoxic T-cells during immune surveillance. Besides plasma, ZAG is found in liver, as well as bodily fluids such as sweat, saliva, cerebrospinal fluid, seminal plasm, milk, ammniotic fluid, and urine. In addition, ZAG is found in 40% of breast carcinomas, and in varous tumor cells. In plasma, ZAG’s lipid binding ability may be important for lipid store homeostasis. Additional functions of ZAG may be involved in the regulation of cell proliferation. In vitro, ZAG has ribonuclease activity that is comparable to onconase and less than RNase A. ZAG may also regulate cell adhesion, since Tu-138 oral squamouse cells can attach to a ZAG substratum. This attachment inhibits cell proliferation and may involve interaction with integrin alpha5beta1 receptors. Thus, ZAG may be a multi-functional protein involved in lipid storage, cell adhesion, and cell differentiation.
Molecular Weight 41 kDa
Pathways Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.
Supplier Images
Western Blotting (WB) image for anti-alpha-2-Glycoprotein 1, Zinc-Binding (AZGP1) (AA 7-102) antibody (ABIN968832) Western blot analysis of Zn-alpha2-glycoprotein on human plasma lysate. Lane 1: 1:250...
Product cited in: Kennedy, Heikema, Cooper, Bjorkman, Sanchez: "Hydrophobic ligand binding by Zn-alpha 2-glycoprotein, a soluble fat-depleting factor related to major histocompatibility complex proteins." in: The Journal of biological chemistry, Vol. 276, Issue 37, pp. 35008-13, 2001 (PubMed).

Lei, Brysk, Arany, Tyring, Srinivasan, Brysk: "Characterization of zinc-alpha(2)-glycoprotein as a cell adhesion molecule that inhibits the proliferation of an oral tumor cell line." in: Journal of cellular biochemistry, Vol. 75, Issue 1, pp. 160-9, 1999 (PubMed).

Lei, Arany, Tyring, Brysk, Brysk: "Zinc-alpha 2-glycoprotein has ribonuclease activity." in: Archives of biochemistry and biophysics, Vol. 355, Issue 2, pp. 160-4, 1998 (PubMed).

Sánchez, López-Otín, Bjorkman: "Biochemical characterization and crystalization of human Zn-alpha2-glycoprotein, a soluble class I major histocompatibility complex homolog." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 9, pp. 4626-30, 1997 (PubMed).

Ueyama, Niwa, Tada, Sasaki, Ohkubo: "Cloning and nucleotide sequence of a human Zn-alpha 2-glycoprotein cDNA and chromosomal assignment of its gene." in: Biochemical and biophysical research communications, Vol. 177, Issue 2, pp. 696-703, 1991 (PubMed).

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