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JNK antibody (pThr183)

MAPK8 Reactivity: Human, Mouse, Rat WB, FACS Host: Mouse Monoclonal 41-JNK-SAPK unconjugated
Catalog No. ABIN968866
  • Target See all JNK (MAPK8) Antibodies
    JNK (MAPK8) (Mitogen-Activated Protein Kinase 8 (MAPK8))
    Binding Specificity
    • 57
    • 28
    • 17
    • 16
    • 16
    • 10
    • 9
    • 9
    • 8
    • 8
    • 8
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pThr183
    Reactivity
    • 209
    • 114
    • 99
    • 43
    • 34
    • 20
    • 18
    • 9
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 196
    • 18
    • 3
    Mouse
    Clonality
    • 180
    • 37
    Monoclonal
    Conjugate
    • 102
    • 18
    • 16
    • 13
    • 12
    • 10
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    This JNK antibody is un-conjugated
    Application
    • 164
    • 93
    • 55
    • 43
    • 40
    • 39
    • 37
    • 31
    • 20
    • 18
    • 14
    • 12
    • 10
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS)
    Cross-Reactivity
    Mouse (Murine), Rat (Rattus)
    Characteristics
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Phosphorylated Human JNK/SAPK (pT183/pY185) Peptide
    Clone
    41-JNK-SAPK
    Isotype
    IgG1
    Top Product
    Discover our top product MAPK8 Primary Antibody
  • Comment

    Related Products: ABIN968535, ABIN968632, ABIN967389, ABIN968074

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store undiluted at -20°C.
  • Fleming, Armstrong, Morrice, Paterson, Goedert, Cohen: "Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7." in: The Biochemical journal, Vol. 352 Pt 1, Issue 3, pp. 145-54, (2001) (PubMed).

    Kyriakis, Avruch: "Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation." in: Physiological reviews, Vol. 81, Issue 2, pp. 807-69, (2001) (PubMed).

    Muyembe, Maes, Makulu, Ghysels, Vandeven, Vandepitte: "The hem of the garment." in: Seminars in dialysis, Vol. 14, Issue 1, pp. 76, (2001) (PubMed).

    Hinton, Henderson, Blanks, Rudnicka, Miller: "Monoclonal antibodies react with neuronal subpopulations in the human nervous system." in: The Journal of comparative neurology, Vol. 267, Issue 3, pp. 398-408, (1988) (PubMed).

  • Target
    JNK (MAPK8) (Mitogen-Activated Protein Kinase 8 (MAPK8))
    Alternative Name
    JNK (MAPK8 Products)
    Synonyms
    JNK antibody, JNK-46 antibody, JNK1 antibody, JNK1A2 antibody, JNK21B1/2 antibody, PRKM8 antibody, SAPK1 antibody, SAPK1c antibody, AI849689 antibody, Prkm8 antibody, BSK antibody, BSK/DJNK antibody, Bsk antibody, CG5680 antibody, D-JNK antibody, D-junk antibody, DBSK/JNK antibody, DJNK antibody, DJNK/bsk antibody, Dmel\\CG5680 antibody, JNK/SAPK antibody, Jnk antibody, Junk antibody, SAPKa antibody, c-Jun antibody, dJNK antibody, jnk antibody, T10F20.15 antibody, jnk1 antibody, sapk1 antibody, mapk8 antibody, zgc:112379 antibody, JNKb antibody, mapk8b antibody, mitogen-activated protein kinase 8 antibody, Stress-activated protein kinase jnk-1 antibody, basket antibody, Protein kinase superfamily protein antibody, mitogen-activated protein kinase 8 L homeolog antibody, mitogen-activated protein kinase 8b antibody, mitogen-activated protein kinase 8B-like antibody, MAPK8 antibody, jnk-1 antibody, Mapk8 antibody, bsk antibody, ATMPK8 antibody, mapk8.L antibody, mapk8b antibody, LOC109094263 antibody
    Background
    The Ras signaling pathway links the signals from growth factor receptors with the activation of the MAPK kinase cascade of phosphorylation leading to cell growth and differentiation. External stimuli, like endotoxins, UV irradiation, heat, and hyperosmolarity, induce an array of cellular responses that culminate with gene expression, ultimately dictating an adaptation to the new environment. Small GTPases of the Rho family, including cdc42, Rac1, and Rho, transmit the stress signals that initiate the signal cascade. JNK is a c-Jun kinase that was also identified as SAPK1 and MAPKp49. JNK/SAPK, along with p38 and RK5/BMK1, comprise three classes of stress-activated MAPK groups. Complete activation of JNK/SAPK requires the phosphorylation of both Thr183 and Tyr185, which are located in a Thr-X-Tyr motif. The activation of these residues is believed to be carried out by MKK4 and MKK7. Active JNK/SAPK phosphorylates other kinases and multiple transcription factors that induce expression of genes, such as proinflammatory cytokines.
    Molecular Weight
    43 & 56 kDa
    Pathways
    MAPK Signaling, WNT Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, Signaling of Hepatocyte Growth Factor Receptor, S100 Proteins
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