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ARC (AA 264-385) antibody

Details for Product No. ABIN968889, Supplier: Login to see
Antigen
Epitope
AA 264-385
20
9
7
3
3
3
3
2
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
60
24
23
3
1
Host
Mouse
57
4
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
1
1
1
1
1
1
Application
Western Blotting (WB)
57
33
26
2
2
1
1
1
Supplier
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Immunogen Rat Arc aa. 264-385
Clone 40-Arc
Isotype IgG1
Cross-Reactivity Mouse (Murine), Human
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Background Immediate early genes (IEGs) are the first to be transcribed upon cellular stimulation. Two groups of these genes have been characterized: those which encode transcription factors that indirectly influence cellular activity, and those which encode effector proteins that directly affect cellular activity. Arc (Activity-Regulated Cytoskeleton-associated protein) encodes an effector protein associated with the actin cytoskeletal matrix. In activated neurons of the hippocampus, Arc gene expression is rapidly induced. Arc protein is concentrated in the actin cortex, adjacent to the plasma membrane of the cell body and dendrites. Arc has a putative role in the maintenance of neuronal plasticity and in activity-dependent changes in dendrite function. Cocaine and D2 receptor antagonists are known to trigger the production and localization of Arc to dendrites and neuronal cell bodies.
Synonyms: Activity-Regulated Cytoskeleton-associated protein
Molecular Weight 55 kDa
Pathways
Comment

Related Products: ABIN968545, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.
Supplier Images
Western Blotting (WB) image for anti-ARC (AA 264-385) antibody (ABIN968889) Western blot analysis of Arc on a rat cerebrum lysate. Lane 1: 1:250, lane 2: 1:500, ...
Product cited in: Vazdarjanova, McNaughton, Barnes et al.: "Experience-dependent coincident expression of the effector immediate-early genes arc and Homer 1a in hippocampal and neocortical neuronal networks." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 22, Issue 23, pp. 10067-71, 2002 (PubMed).

Lyford, Yamagata, Kaufmann et al.: "Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites." in: Neuron, Vol. 14, Issue 2, pp. 433-45, 1995 (PubMed).