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SLU7 antibody (AA 457-570)

SLU7 Reactivity: Human, Mouse, Rat, Dog, Chicken WB, IF Host: Mouse Monoclonal 35-hSlu7 unconjugated
Catalog No. ABIN968890
  • Target See all SLU7 Antibodies
    SLU7 (SLU7 Splicing Factor Homolog (SLU7))
    Binding Specificity
    • 15
    • 8
    • 8
    • 6
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 457-570
    Reactivity
    • 54
    • 13
    • 11
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Dog, Chicken
    Host
    • 50
    • 5
    Mouse
    Clonality
    • 51
    • 4
    Monoclonal
    Conjugate
    • 27
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SLU7 antibody is un-conjugated
    Application
    • 50
    • 29
    • 13
    • 13
    • 5
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Cross-Reactivity
    Dog (Canine), Rat (Rattus), Mouse (Murine)
    No Cross-Reactivity
    Chicken
    Characteristics
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human hSlu7 aa. 457-570
    Clone
    35-hSlu7
    Isotype
    IgG2b
    Top Product
    Discover our top product SLU7 Primary Antibody
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store undiluted at -20° C.
  • Chua, Reed: "The RNA splicing factor hSlu7 is required for correct 3' splice-site choice." in: Nature, Vol. 402, Issue 6758, pp. 207-10, (2000) (PubMed).

    Chua, Reed: "Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing." in: Genes & development, Vol. 13, Issue 7, pp. 841-50, (1999) (PubMed).

  • Target
    SLU7 (SLU7 Splicing Factor Homolog (SLU7))
    Alternative Name
    hSlu7 (SLU7 Products)
    Synonyms
    9G8 antibody, hSlu7 antibody, AU018913 antibody, D11Ertd730e antibody, D3Bwg0878e antibody, 9g8 antibody, hslu7 antibody, wu:fc94e11 antibody, zgc:103640 antibody, CG1420 antibody, Dmel\\CG1420 antibody, SLU7 antibody, SLU7 homolog, splicing factor antibody, SLU7 splicing factor homolog (S. cerevisiae) antibody, SLU7 homolog, splicing factor L homeolog antibody, CG1420 gene product from transcript CG1420-RA antibody, SLU7 antibody, Slu7 antibody, slu7.L antibody, slu7 antibody
    Target Type
    Influenza Protein
    Background
    Splicing, the removal of introns from pre-mRNA, is mediated by spliceosomal complexes and occurs in two distinct catalytic steps. The first step involves cleavage of the 5' exon and the production of a lariat intermediate. In the second step, the 3' splice site is cleaved and the exons are fused with concomitant release of the intron lariat. The spliceosome contains multiple snRNPs and a number of non-snRNP splicing factors. Four yeast proteins (Prp16p, Prp17p, Prp18p, and Slu7p) function exclusively in the second catalytic step. Human homologs have been identified for Prp16p (hPrp16), Prp17p (hPrp17), Prp18p (hPrp18) and Slu7 (hSlu7). hSlu7 contains a zinc knuckle motif similar to the yeast Slu7. This domain is present in retroviral nucleocapsid proteins and in several splicing factors. hSlu7 associates with the spliceosome late in the splicing pathway during recognition of the 3' splice site. During step II of 3' splicing, hSlu7 tightly binds to exon 1 in the spliceosome and helps specify attack on the correct adenine-guanine dinucleotide, located 18 to 40 nucleotides downstream of the branch site.
    Molecular Weight
    80 kDa
    Pathways
    Ribonucleoprotein Complex Subunit Organization, SARS-CoV-2 Protein Interactome
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