Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

OPA1 antibody (AA 708-830)

OPA1 Reactivity: Human, Mouse, Rat, Chicken, Dog WB, IF Host: Mouse Monoclonal 18-OPA1 unconjugated
Catalog No. ABIN968891
  • Target See all OPA1 Antibodies
    OPA1 (Optic Atrophy 1 (Autosomal Dominant) (OPA1))
    Binding Specificity
    • 15
    • 4
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 708-830
    Reactivity
    • 46
    • 29
    • 29
    • 17
    • 17
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Chicken, Dog
    Host
    • 42
    • 4
    Mouse
    Clonality
    • 35
    • 11
    Monoclonal
    Conjugate
    • 19
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This OPA1 antibody is un-conjugated
    Application
    • 30
    • 14
    • 14
    • 12
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Cross-Reactivity
    Dog (Canine), Rat (Rattus), Mouse (Murine), Chicken
    Characteristics
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human OPA1 aa. 708-830
    Clone
    18-OPA1
    Isotype
    IgG1
    Top Product
    Discover our top product OPA1 Primary Antibody
  • Comment

    Related Products: ABIN968586, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store undiluted at -20° C.
  • Misaka, Miyashita, Kubo: "Primary structure of a dynamin-related mouse mitochondrial GTPase and its distribution in brain, subcellular localization, and effect on mitochondrial morphology." in: The Journal of biological chemistry, Vol. 277, Issue 18, pp. 15834-42, (2002) (PubMed).

    Alexander, Votruba, Pesch, Thiselton, Mayer, Moore, Rodriguez, Kellner, Leo-Kottler, Auburger, Bhattacharya, Wissinger: "OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28." in: Nature genetics, Vol. 26, Issue 2, pp. 211-5, (2000) (PubMed).

    Delettre, Lenaers, Griffoin, Gigarel, Lorenzo, Belenguer, Pelloquin, Grosgeorge, Turc-Carel, Perret, Astarie-Dequeker, Lasquellec, Arnaud, Ducommun, Kaplan, Hamel: "Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy." in: Nature genetics, Vol. 26, Issue 2, pp. 207-10, (2000) (PubMed).

  • Target
    OPA1 (Optic Atrophy 1 (Autosomal Dominant) (OPA1))
    Alternative Name
    OPA1 (OPA1 Products)
    Synonyms
    1200011N24Rik antibody, AI225888 antibody, AI847218 antibody, lilr3 antibody, mKIAA0567 antibody, MGM1 antibody, NPG antibody, NTG antibody, largeG antibody, fk62d06 antibody, wu:fb77a10 antibody, wu:fk62d06 antibody, zgc:92092 antibody, OPA1, mitochondrial dynamin like GTPase antibody, optic atrophy 1 (autosomal dominant) antibody, Opa1 antibody, OPA1 antibody, opa1 antibody
    Background
    Three major GTP-binding protein families include trimeric and low molecular weight G-proteins, as well as a family of large proteins homologous to dynamin. The dynamin family contains proteins with diverse structure and function, but highly homologous N-terminal GTPase domains. A subgroup of the dynamin G-protein-binding family includes the mitochondrial proteins Drp1/Dnm1, Mgm1, and OPA1. The latter protein is mutated in dominant optic atrophy, a disease that involves loss of visual acuity and atrophy of the optic nerve. OPA1 is expressed in heart, brain, liver, and kidney. The sequence of OPA1 includes an N-terminal region that contains a mitochondrial targeting domain and three GTP-binding motifs. The overexpression of OPA1 in Cos-7 cells shows co-localization with cytochrome c in mitochondria, and leads to alterations in mitochondrial morphology from a characteristic tubuluar shape to a vesicular pattern. Thus, OPA1 may have roles in mitochondrial biogenesis that are critical for normal cell function. This antibody is routinely tested by western blot analysis.
    Molecular Weight
    80-100 kDa
    Pathways
    Tube Formation
You are here:
Support