AAT antibody

Catalog No. ABIN968939

Product Details

Target: AAT

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Purification: purified

Immunogen: Purified recombinant fragment of human AAT expressed in E. coli.

Clone: 2B12

Isotype: IgG1

Application Details

Application Notes: ELISA: 1:10000, WB: 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

References

El-Akawi, Al-Hindawi, Bashir: "Alpha-1 antitrypsin (alpha1-AT) plasma levels in lung, prostate and breast cancer patients." in: Neuro endocrinology letters, Vol. 29, Issue 4, pp. 482-4, (2008) (PubMed).

Liu, Qian, Gritsenko, Camp, Monroe, Moore, Smith: "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." in: Journal of proteome research, Vol. 4, Issue 6, pp. 2070-80, (2005) (PubMed).

Target Details

Target: AAT

Synonyms: A1A antibody, A1AT antibody, AAT antibody, PI antibody, PI1 antibody, PRO2275 antibody, alpha1AT antibody, serpin family A member 1 antibody, SERPINA1 antibody

Background:

Description: AAT, also known as SERPINA1, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1. It is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Severe Serpin A1 deficiency leads to several clinical complications such as pulmonary emphysema, juvenile hepatisis, cirrhosis and hepatocellular carcinoma.

Aliases: PI, A1A, AAT, PI1, A1AT, SERPINA1

Molecular Weight: 47 kDa

Gene ID: 5265

HGNC: 5265