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Details for Product No. ABIN968960

Apoa5(bd) (AA 180-363) antibody

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Antigen
Epitope
AA 180-363
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Application
»Alternatives ELISA
Pubmed 2 references available
Catalog no. ABIN968960
Quantity 100 µL
Price
451.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 3 to 4 Business Days
Immunogen Purified recombinant fragment of human APOA5 (AA 180-363) expressed in E. coli.
Clone 4H8H8E2(c)
Isotype IgG1
Purification Ascites
Alternative Name Apoa5 (bd)
Background Synonyms:
RAP3, APOAV, APOA-V
Apolipoprotein A5 (ApoA5) is fast gaining attention as a key regulator of serum triglyceride concentrations. An ApoA5 mouse knock-out model produced an approximately four fold increase in serum triglyc erides, whereas a knock-in model with human ApoA5 produced 50–70 % lower,, concentrations of mouse serum triglycerides. In addition, peroxisome proliferator-activated receptor-_ agonists, which are used clinically to lower serum triglyceride concentrations, cause increased ApoA5 mRNA expression. Recently, it was demonstrated that ApoA5 is present in human serum detected by polyclonal antibodies against both the NH2 and COOH termini, although at much lower concentration than other apolipoproteins.
Molecular Weight 41.2 kDa
Gene ID 116519
Application Notes Recommended Dilution:
ELISA: 1/10000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Product cited in: Pennacchio, Olivier, Hubacek et al.: "An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing." in: Science (New York, N.Y.), Vol. 294, Issue 5540, pp. 169-73, 2001 (PubMed).

Prieur, Coste, Rodriguez: "The human apolipoprotein AV gene is regulated by peroxisome proliferator-activated receptor-alpha and contains a novel farnesoid X-activated receptor response element." in: The Journal of biological chemistry, Vol. 278, Issue 28, pp. 25468-80, 2003 (PubMed).

Alternatives for antigen "Apoa5(bd)", type "Antibodies"
Hosts (1)
Reactivities (2)
Applications (2), (2), (1)
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