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APOE antibody

APOE Reactivity: Human WB, ELISA, IHC, FACS Host: Mouse Monoclonal 1H4 unconjugated
Catalog No. ABIN968962
  • Target See all APOE Antibodies
    APOE (Apolipoprotein E (APOE))
    Reactivity
    • 101
    • 75
    • 56
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 103
    • 21
    • 13
    • 2
    Mouse
    Clonality
    • 105
    • 33
    Monoclonal
    Conjugate
    • 59
    • 18
    • 12
    • 7
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    This APOE antibody is un-conjugated
    Application
    • 110
    • 56
    • 39
    • 39
    • 29
    • 25
    • 20
    • 12
    • 10
    • 9
    • 7
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)
    Purification
    purified
    Immunogen
    Purified recombinant fragment of human ApoE expressed in E. coli.
    Clone
    1H4
    Isotype
    IgG1
    Top Product
    Discover our top product APOE Primary Antibody
  • Application Notes
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, FCM: 1:200 - 1:400
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    4°C, -20°C for long term storage
  • Karpouzis, Caridha, Tripsianis, Michailidis, Martinis, Veletza: "Apolipoprotein E gene polymorphism in psoriasis." in: Archives of dermatological research, Vol. 301, Issue 6, pp. 405-10, (2009) (PubMed).

    Zintzaras, Kitsios, Triposkiadis, Lau, Raman: "APOE gene polymorphisms and response to statin therapy." in: The pharmacogenomics journal, Vol. 9, Issue 4, pp. 248-57, (2009) (PubMed).

  • Target
    APOE (Apolipoprotein E (APOE))
    Alternative Name
    ApoE (APOE Products)
    Synonyms
    ad2 antibody, apoprotein antibody, im:7036787 antibody, wu:fb69a05 antibody, zgc:110064 antibody, apoe antibody, AI255918 antibody, AD2 antibody, LDLCQ5 antibody, LPG antibody, APOEA antibody, Apo-E antibody, apolipoprotein E antibody, apolipoprotein Ea antibody, apoe antibody, apoea antibody, Apoe antibody, APOE antibody
    Background

    Description: Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. Tissue specificity: Occurs in all lipoprotein fractions in plasma. It constitutes 10-20 % of very low density lipoproteins (VLDL) and 1-2 % of high density lipoproteins (HDL). APOE is produced in most organs. Significant quantities are produced in liver, brain, spleen, lung, adrenal, ovary, kidney and muscle.

    Aliases: AD2, LPG, LDLCQ5, MGC1571

    Molecular Weight
    36 kDa
    Gene ID
    348
    HGNC
    348
    Pathways
    Regulation of Cell Size, Lipid Metabolism
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