BMP4 antibody (Bone Morphogenetic Protein 4)

Details for Product anti-BMP4 Antibody No. ABIN968986, Supplier: Log in to see
Antigen
  • bmp-4
  • zbmp-4
  • zgc:100779
  • XBMP-4
  • bmp2b
  • bmp2b1
  • bmp4
  • ofc11
  • xbmp4
  • zyme
  • BMP4
  • bmp-2
  • bmp2
  • bmp2-4
  • cb670
  • zbmp-2
  • zbmp2
  • BMP2B
  • BMP2B1
  • MCOPS6
  • OFC11
  • ZYME
  • Bmp-4
  • Bmp2b
  • Bmp2b-1
  • Bmp2b1
  • BOMPR4A
  • BMP-4
  • bone morphogenetic protein 4
  • Bone morphogenetic protein 4
  • bone morphogenetic protein 2b
  • bmp4
  • bmp4-a
  • BMP4
  • LOC100286408
  • bmp2b
  • bmp4-b
  • Bmp4
Alternatives
anti-Human BMP4 antibody for Neutralization
Reactivity
Human
218
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64
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15
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12
6
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3
3
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2
1
1
1
Host
Mouse
165
101
9
1
1
Clonality (Clone)
Monoclonal ()
Conjugate
This BMP4 antibody is un-conjugated
23
19
9
6
4
4
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3
3
3
3
3
3
3
3
3
3
3
2
2
1
1
1
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1
Application
ELISA, Western Blotting (WB)
218
161
111
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24
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13
11
11
9
4
3
3
2
1
1
1
1
1
Options
Supplier
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Supplier Product No.
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Immunogen Purified recombinant fragment of human BMP4 expressed in E. Coli.
Clone 10F4B4
Isotype IgG1
Purification Ascites
Alternative Name BMP4 (BMP4 Antibody Abstract)
Background The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors.BMPs (bone morphogenetic proteins) belong to the TGF beta superfamily of structurally related signaling proteins. Members of this superfamily are widely represented throughout the animal kingdom and have been implicated in a variety of developmental processes. Proteins of the TGF beta superfamily are disulfide-linked dimers composed of two 12-15 kDa polypeptide chains. As implied by their name, BMPs initiate, promote and regulate bone development, growth, remodeling and repair. Smad1 translocation to the nucleus is observed after the addition of BMP4 (also designated BMP2B), suggesting that BMP4 may play a role in activation of the Smad pathway. BMP is secreted into the extracellular matrix.
Molecular Weight 64 kDa
Gene ID 652
HGNC 652
Research Area Organogenesis, Growth Factors, Angiogenesis, Signaling
Pathways Steroid Hormone Mediated Signaling Pathway, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development
Application Notes ELISA: 1:10000, WB: 1:500 - 1:2000
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage
Supplier Images
Western Blotting (WB) image for anti-Bone Morphogenetic Protein 4 (BMP4) antibody (ABIN968986) Figure 1: Western blot analysis using BMP4 mouse mAb against BMP4-hIgGFc transfected ...
Product cited in: Solmesky, Abekasis, Bulvik, Weil: "Bone morphogenetic protein signaling is involved in human mesenchymal stem cell survival in serum-free medium." in: Stem cells and development, Vol. 18, Issue 9, pp. 1283-92, 2009 (PubMed).

Yerges, Klei, Cauley, Roeder, Kammerer, Moffett, Ensrud, Nestlerode, Marshall, Hoffman, Lewis, Lang, Barrett-Connor, Ferrell, Orwoll, Zmuda: "High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 24, Issue 12, pp. 2039-49, 2009 (PubMed).

Background publications Oida, Iimura, Maruoka, Takeda, Sasaki: "Cloning and sequence of bone morphogenetic protein 4 (BMP-4) from a human placental cDNA library." in: DNA sequence : the journal of DNA sequencing and mapping, Vol. 5, Issue 5, pp. 273-5, 1995 (PubMed).

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