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BTK antibody

BTK Reactivity: Human, Monkey WB, ELISA, IHC, ICC Host: Mouse Monoclonal 7F12H4 unconjugated
Catalog No. ABIN968992
  • Target See all BTK Antibodies
    BTK (Bruton Agammaglobulinemia tyrosine Kinase (BTK))
    Reactivity
    • 147
    • 90
    • 79
    • 13
    • 6
    • 4
    • 2
    Human, Monkey
    Host
    • 170
    • 8
    Mouse
    Clonality
    • 145
    • 34
    Monoclonal
    Conjugate
    • 69
    • 15
    • 12
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 7
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    This BTK antibody is un-conjugated
    Application
    • 107
    • 66
    • 40
    • 40
    • 36
    • 27
    • 18
    • 16
    • 10
    • 10
    • 9
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)
    Purification
    purified
    Immunogen
    Purified recombinant fragment of BTK expressed in E. coli.
    Clone
    7F12H4
    Isotype
    IgG1
    Top Product
    Discover our top product BTK Primary Antibody
  • Application Notes
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    4°C, -20°C for long term storage
  • Target
    BTK (Bruton Agammaglobulinemia tyrosine Kinase (BTK))
    Alternative Name
    BTK (BTK Products)
    Synonyms
    BTK antibody, atk antibody, bpk antibody, xla antibody, imd1 antibody, agmx1 antibody, psctk1 antibody, AGMX1 antibody, AT antibody, ATK antibody, BPK antibody, IMD1 antibody, PSCTK1 antibody, XLA antibody, AI528679 antibody, xid antibody, Bruton tyrosine kinase antibody, Bruton agammaglobulinemia tyrosine kinase antibody, BTK antibody, btk antibody, Btk antibody
    Background

    Description: Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases.All members of the family contain SH3 and SH2 domains and, with the exception of Txk and Dsrc28C, also contain a pleckstrin homology (PH) and a Tec homology (TH) domain in their amino termini.BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation.

    Aliases: BTK

    Molecular Weight
    77 kDa
    Gene ID
    695
    HGNC
    695
    Pathways
    Fc-epsilon Receptor Signaling Pathway, Hormone Transport, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, BCR Signaling
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