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NFkB cRel antibody

Details for Product No. ABIN968997, Supplier: Log in to see
Antigen
  • NFkB
Reactivity
Human, Mouse (Murine)
88
38
13
1
1
1
Host
Mouse
78
13
3
3
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
Application
Immunocytochemistry (ICC), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
60
24
21
18
14
12
4
3
2
2
2
1
1
1
Supplier
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Immunogen Purified recombinant fragment of human c-Rel expressed in E. coli.
Clone 1-00E-07
Isotype IgG1
Purification Ascites
Alternative Name C-Rel
Background The REL gene encodes c-Rel, a transcription factor that is a member of the Rel/NFKB family, which also includes RELA (MIM 164014), RELB (604758), NFKB1 (MIM 164011), and NFKB2 (MIM 164012). These proteins are related through a highly conserved N-terminal region termed the 'Rel domain,' which is responsible for DNA binding, dimerization, nuclear localization, and binding to the NFKB inhibitor.
Molecular Weight 78 kDa
Gene ID 5966
HGNC 5966
Research Area Cancer, Transcription Factors
Pathways
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, ICC: 1/200 - 1/1000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
ELISA image for anti-NFkB cRel antibody (ABIN968997) Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 n...
Immunocytochemistry (ICC) image for anti-NFkB cRel antibody (ABIN968997) Figure 2: Immunofluorescence analysis of U251 cells using c-Rel mouse mAb (green) . B...
Immunohistochemistry (IHC) image for anti-NFkB cRel antibody (ABIN968997) Figure 3: Immunohistochemical analysis of paraffin-embedded endometrial cancer tissue...
Western Blotting (WB) image for anti-NFkB cRel antibody (ABIN968997) Figure 4: Western blot analysis using c-Rel mouse mAb against Jurkat (1), NIH/3T3 (2)...
Product cited in: Trynka, Zhernakova, Romanos et al.: "Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. ..." in: Gut, Vol. 58, Issue 8, pp. 1078-83, 2009 (PubMed).

Garbati, Gilmore: "Ser484 and Ser494 in REL are the major sites of IKK phosphorylation in vitro: evidence that IKK does not directly enhance GAL4-REL transactivation." in: Gene expression, Vol. 14, Issue 4, pp. 195-205, 2008 (PubMed).