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p65 antibody (Nuclear Factor-KB P65)

Details for Product anti-NFkBP65 Antibody No. ABIN968997, Supplier: Log in to see
Antigen
  • NFKB3
  • p65
  • NFkB
  • v-rel avian reticuloendotheliosis viral oncogene homolog A
  • v-rel reticuloendotheliosis viral oncogene homolog A (avian)
  • RELA
  • Rela
Alternatives
anti-Human p65 antibody for Western Blotting
Reactivity
Human, Mouse (Murine)
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688
544
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29
28
23
21
12
8
8
8
4
4
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2
1
1
1
1
1
Host
Mouse
1042
140
16
10
7
1
Clonality (Clone)
Monoclonal ()
Conjugate
This p65 antibody is un-conjugated
35
35
27
21
18
16
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16
11
11
11
9
9
9
9
9
9
6
6
4
4
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3
3
2
2
2
2
2
2
1
Application
Immunocytochemistry (ICC), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
886
456
370
247
218
149
118
83
71
30
18
18
17
11
11
6
6
6
5
4
4
2
2
1
1
Options
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Immunogen Purified recombinant fragment of human c-Rel expressed in E. coli.
Clone 1-00E-07
Isotype IgG1
Purification Ascites
Alternative Name C-Rel (NFkBP65 Antibody Abstract)
Background The REL gene encodes c-Rel, a transcription factor that is a member of the Rel/NFKB family, which also includes RELA (MIM 164014), RELB (604758), NFKB1 (MIM 164011), and NFKB2 (MIM 164012). These proteins are related through a highly conserved N-terminal region termed the 'Rel domain,' which is responsible for DNA binding, dimerization, nuclear localization, and binding to the NFKB inhibitor.
Molecular Weight 78 kDa
Gene ID 5966
HGNC 5966
Research Area Cancer, Transcription Factors
Pathways NF-kappaB Signaling, RTK Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, ICC: 1/200 - 1/1000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
ELISA image for anti-p65 antibody (Nuclear Factor-KB P65) (ABIN968997) Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 n...
Immunocytochemistry (ICC) image for anti-p65 antibody (Nuclear Factor-KB P65) (ABIN968997) Figure 2: Immunofluorescence analysis of U251 cells using c-Rel mouse mAb (green) . B...
Immunohistochemistry (IHC) image for anti-p65 antibody (Nuclear Factor-KB P65) (ABIN968997) Figure 3: Immunohistochemical analysis of paraffin-embedded endometrial cancer tissue...
Western Blotting (WB) image for anti-p65 antibody (Nuclear Factor-KB P65) (ABIN968997) Figure 4: Western blot analysis using c-Rel mouse mAb against Jurkat (1), NIH/3T3 (2)...
Product cited in: Trynka, Zhernakova, Romanos, Franke, Hunt, Turner, Bruinenberg, Heap, Platteel, Ryan, de Kovel, Holmes, Howdle, Walters, Sanders, Mulder, Mearin, Verbeek, Trimble, Stevens, Kelleher, Barisani et al.: "Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. ..." in: Gut, Vol. 58, Issue 8, pp. 1078-83, 2009 (PubMed).

Garbati, Gilmore: "Ser484 and Ser494 in REL are the major sites of IKK phosphorylation in vitro: evidence that IKK does not directly enhance GAL4-REL transactivation." in: Gene expression, Vol. 14, Issue 4, pp. 195-205, 2008 (PubMed).

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