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CD34 antibody (CD34 Molecule)

Details for Product anti-CD34 Antibody No. ABIN969021, Supplier: Log in to see
Antigen
  • AU040960
Reactivity
Human
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Host
Mouse
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3
Clonality (Clone)
Monoclonal ()
Conjugate
This CD34 antibody is un-conjugated
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10
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Application
Immunocytochemistry (ICC), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
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Supplier
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Immunogen Purified recombinant fragment of CD34 expressed in E. coli.
Clone 4H5E7
Isotype IgG
Purification Ascites
Alternative Name CD34 (CD34 Antibody Abstract)
Background CD34 is a transmembrane glycoprotein with a molecular mass of approximately 110 kD that is selectively expressed on human hematopoietic progenitor cells, endothelial cells and some fibroblasts. It could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is highly expressed on hematopoietic progenitors, as well as on endothelial cells. CD34 has been used to measure angiogenesis, which reportedly predicts tumor recurrence.
Gene ID 947
HGNC 947
Research Area Hematopoietic Progenitors, Hematopoietic Stem Cells, Cardiogenesis, Lineage Markers, CD Antigens, Surface Receptors of Immune Cells
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, ICC: 1/200 - 1/1000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
Immunocytochemistry (ICC) image for anti-CD34 antibody (CD34 Molecule) (ABIN969021) Figure 1: Immunofluorescence analysis of peripheral blood cells using CD34 mouse mAb.
Immunohistochemistry (IHC) image for anti-CD34 antibody (CD34 Molecule) (ABIN969021) Figure 2: Immunohistochemical analysis of paraffin-embedded human spleen using CD34 m...
Western Blotting (WB) image for anti-CD34 antibody (CD34 Molecule) (ABIN969021) Figure 3: Western blot analysis using CD34 mouse mAb against truncated CD34 recombina...
Product cited in: Sho, Sho, Nanjo et al.: "Hemodynamic regulation of CD34+ cell localization and differentiation in experimental aneurysms." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 24, Issue 10, pp. 1916-21, 2004 (PubMed).

Background publications Krause, Ito, Fackler et al.: "Characterization of murine CD34, a marker for hematopoietic progenitor and stem cells." in: Blood, Vol. 84, Issue 3, pp. 691-701, 1994 (PubMed).

Satterthwaite, Burn, Le Beau et al.: "Structure of the gene encoding CD34, a human hematopoietic stem cell antigen." in: Genomics, Vol. 12, Issue 4, pp. 788-94, 1992 (PubMed).