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E-cadherin antibody (Cadherin 1, Type 1, E-Cadherin (Epithelial))

Details for Product anti-CDH1 Antibody No. ABIN969037, Supplier: Log in to see
Antigen
  • E-Cad
  • E-cadherin
  • XB-cadherin
  • XBcad
  • XTCAD-1
  • b-cadherin
  • cadherin-1
  • cdh1-a
  • cdhc-A
  • cdhp
  • hjmd
  • l-cam
  • lcam
  • pcad
  • uvo
  • uvomorulin
  • xb-cad
  • xcdh1
  • Arc1
  • AA960649
  • E-cad
  • Ecad
  • L-CAM
  • UVO
  • Um
  • Arc-1
  • CD324
  • CDHE
  • ECAD
  • LCAM
  • arc-1
  • cd324
  • cdhe
  • ecad
  • cdh1
  • si:dz180o5.2
Reactivity
Human, Mouse (Murine), Monkey
428
130
95
21
20
11
6
4
4
3
2
1
1
1
1
1
1
1
1
1
1
1
Host
Mouse
254
193
18
17
1
1
Clonality (Clone)
Monoclonal ()
Conjugate
This E-cadherin antibody is un-conjugated
29
24
18
13
10
7
6
5
4
4
3
3
3
3
3
3
2
1
1
1
Application
ELISA, Western Blotting (WB)
309
142
100
95
93
58
48
43
36
32
13
9
6
4
2
2
2
2
2
1
1
1
1
1
Supplier
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Supplier Product No.
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Immunogen Purified recombinant fragment of human CDH1 expressed in E. coli.
Clone 7A2
Isotype IgG1
Purification Ascites
Alternative Name CDH1 (CDH1 Antibody Abstract)
Background E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues.
Molecular Weight 135 kDa
Gene ID 999
HGNC 999
Research Area Proteolysis / Ubiquitin
Pathways
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
Western Blotting (WB) image for anti-E-cadherin antibody (Cadherin 1, Type 1, E-Cadherin (Epithelial)) (ABIN969037) Figure 1: Western blot analysis using CDH1 mouse mAb against LNCAP (1) ,A431 (2), DU1...
Product cited in: Schietke, Warnecke, Wacker et al.: "The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1." in: The Journal of biological chemistry, Vol. 285, Issue 9, pp. 6658-69, 2010 (PubMed).

Wang, Yao, Zhang et al.: "[Expression and significance of CD147 and E-cadherin in human gastric carcinoma]." in: Zhonghua zhong liu za zhi [Chinese journal of oncology], Vol. 31, Issue 7, pp. 515-9, 2009 (PubMed).

Barrett, Lee, Lees et al.: "Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. ..." in: Nature genetics, Vol. 41, Issue 12, pp. 1330-4, 2009 (PubMed).