conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) (AA 500-590) antibody

Details for Product No. ABIN969054
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Antigen
Synonyms ikk, ikk1, ikka, ikkalpha, CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16, AI256658, Chuk1, Fbx24, Fbxo24, Ikka, zgc:56539
Epitope
AA 500-590
(64), (32), (20), (16), (15), (15), (15), (14), (13), (12), (12), (12), (10), (9), (8), (7), (7), (6), (5), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(335), (112), (84), (1)
Host
Mouse
(285), (53), (10), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(14), (10), (10), (8), (8), (8), (2), (2), (2), (2), (2), (2), (2), (2)
Application
ELISA, Western Blotting (WB)
(308), (140), (103), (44), (40), (40), (33), (20), (10), (9), (9), (3), (2), (2), (1), (1)
Pubmed 2 references available
Quantity 100 μL
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Immunogen Purified recombinant fragment of CHUK (AA 500-590) expressed in E. coli.
Clone 7C10B6
Isotype IgG1
Purification Ascites
Alternative Name CHUK (CHUK Antibody Abstract)
Background CHUK: conserved helix-loop-helix ubiquitous kinase. This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor.
Gene ID 1147
HGNC 1147
Pathways PI3K-Akt Signaling Pathway, NF-kappaB Signaling
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) (AA 500-590) antibody Figure 1: Western blot analysis using CHUK mouse mAb against truncated Trx-CHUK recom...
Product cited in: Prajapati, Verma, Yamamoto et al.: "Protein phosphatase 2Cbeta association with the IkappaB kinase complex is involved in regulating NF-kappaB activity." in: The Journal of biological chemistry, Vol. 279, Issue 3, pp. 1739-46, 2004 (PubMed).

Background publications Soond, Terry, Colbert et al.: "TRUSS, a novel tumor necrosis factor receptor 1 scaffolding protein that mediates activation of the transcription factor NF-kappaB." in: Molecular and cellular biology, Vol. 23, Issue 22, pp. 8334-44, 2003 (PubMed).

Validation Images
Catalog No. ABIN969054
345.40 $
Plus shipping costs $45.00
Quantity
Price
100 μL
345.40 $

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