You are viewing an incomplete version of our website. Please click to reload the website as full version.

CSK antibody (C-Src tyrosine Kinase)

Details for Product anti-CSK Antibody No. ABIN969069, Supplier: Log in to see
Antigen
  • AW212630
  • c-src tyrosine kinase
  • CSK
  • Csk
Alternatives
anti-Human CSK antibody for Immunocytochemistry
Reactivity
Human, Mouse (Murine), Monkey, Rat (Rattus)
198
126
93
11
11
8
6
3
3
2
2
2
2
1
1
Host
Mouse
134
45
23
Clonality (Clone)
Monoclonal ()
Conjugate
This CSK antibody is un-conjugated
7
7
7
6
5
5
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), Flow Cytometry (FACS), ELISA, Western Blotting (WB)
171
79
37
37
30
26
22
19
8
2
2
1
1
1
Options
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

It's quick and easy to submit your validation proposal. I want to validate this product

Learn more

Available images

Immunogen Purified recombinant fragment of human CSK expressed in E. coli.
Clone 5F3
Isotype IgG1
Purification Ascites
Alternative Name CSK (CSK Antibody Abstract)
Background Carboxy-terminal Src kinase (Csk) is a ubiquitously expressed nonreceptor tyrosine kinase that negatively regulates the Src family kinases (SFK) by phosphorylation of the SFK carboxy-terminal tyrosine. Phosphorylated carboxy-terminal tyrosine binds to the SH2 domain of SFK intramolecularly and leads to folding and inactivation of the SFK . This Csk-catalyzed SFK tyrosine phosphorylation is highly specific and exclusive. The SFK carboxy-terminal tyrosine is the only known physiological substrate of Csk .Tissue specificity: Expressed in lung and macrophages.
Molecular Weight 50 kDa
Gene ID 1445
HGNC 1445
Research Area Signaling, Tyrosine Kinases
Pathways EGFR Signaling Pathway, Cell-Cell Junction Organization
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
Flow Cytometry (FACS) image for anti-CSK antibody (C-Src tyrosine Kinase) (ABIN969069) Figure 1: Flow cytometric analysis of HL-60 cells using CSK mouse mAb (green) and neg...
Immunocytochemistry (ICC) image for anti-CSK antibody (C-Src tyrosine Kinase) (ABIN969069) Figure 2: Immunofluorescence analysis of U251 cells using CSK mouse mAb (green) . Blu...
Western Blotting (WB) image for anti-CSK antibody (C-Src tyrosine Kinase) (ABIN969069) Figure 3: Western blot analysis using CSK mouse mAb against NIH/3T3 (1) ,Hela (2) ,CO...
Product cited in: Levy, Ehret, Rice, Verwoert, Launer, Dehghan, Glazer, Morrison, Johnson, Aspelund, Aulchenko, Lumley, Köttgen, Vasan, Rivadeneira, Eiriksdottir, Guo, Arking, Mitchell, Mattace-Raso, Smith, Taylor et al.: "Genome-wide association study of blood pressure and hypertension. ..." in: Nature genetics, Vol. 41, Issue 6, pp. 677-87, 2010 (PubMed).

Ho, Levy, Rose, Johnson, Ridker, Chasman: "Discovery and replication of novel blood pressure genetic loci in the Women's Genome Health Study." in: Journal of hypertension, Vol. 29, Issue 1, pp. 62-9, 2010 (PubMed).

Kreil, Hochhaus, Cross, Chase: "A high-throughput candidate gene mutation screen in lymphoproliferative and myeloproliferative neoplasias." in: Leukemia research, Vol. 33, Issue 9, pp. e168-9, 2009 (PubMed).