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C-Src tyrosine Kinase (CSK) antibody

Details for Product No. ABIN969069, Supplier: Log in to see
Antigen
  • AW212630
Alternatives
anti-Human C-Src tyrosine Kinase antibody for Immunocytochemistry
Reactivity
Human, Mouse (Murine), Monkey, Rat (Rattus)
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77
65
8
6
6
4
1
1
1
1
1
Host
Mouse
129
26
21
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
7
7
7
5
5
5
2
2
2
2
2
2
2
2
2
Application
Immunocytochemistry (ICC), Flow Cytometry (FACS), ELISA, Western Blotting (WB)
147
71
31
22
18
18
16
11
5
3
2
1
1
Supplier
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Immunogen Purified recombinant fragment of human CSK expressed in E. coli.
Clone 5F3
Isotype IgG1
Purification Ascites
Alternative Name CSK (CSK Antibody Abstract)
Background Carboxy-terminal Src kinase (Csk) is a ubiquitously expressed nonreceptor tyrosine kinase that negatively regulates the Src family kinases (SFK) by phosphorylation of the SFK carboxy-terminal tyrosine. Phosphorylated carboxy-terminal tyrosine binds to the SH2 domain of SFK intramolecularly and leads to folding and inactivation of the SFK . This Csk-catalyzed SFK tyrosine phosphorylation is highly specific and exclusive. The SFK carboxy-terminal tyrosine is the only known physiological substrate of Csk .Tissue specificity: Expressed in lung and macrophages.
Molecular Weight 50 kDa
Gene ID 1445
HGNC 1445
Research Area Signaling, Tyrosine Kinases
Pathways EGFR Signaling Pathway
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
Flow Cytometry (FACS) image for anti-C-Src tyrosine Kinase (CSK) antibody (ABIN969069) Figure 1: Flow cytometric analysis of HL-60 cells using CSK mouse mAb (green) and neg...
Immunocytochemistry (ICC) image for anti-C-Src tyrosine Kinase (CSK) antibody (ABIN969069) Figure 2: Immunofluorescence analysis of U251 cells using CSK mouse mAb (green) . Blu...
Western Blotting (WB) image for anti-C-Src tyrosine Kinase (CSK) antibody (ABIN969069) Figure 3: Western blot analysis using CSK mouse mAb against NIH/3T3 (1) ,Hela (2) ,CO...
Product cited in: Ho, Levy, Rose et al.: "Discovery and replication of novel blood pressure genetic loci in the Women's Genome Health Study." in: Journal of hypertension, Vol. 29, Issue 1, pp. 62-9, 2010 (PubMed).

Kreil, Hochhaus, Cross et al.: "A high-throughput candidate gene mutation screen in lymphoproliferative and myeloproliferative neoplasias." in: Leukemia research, Vol. 33, Issue 9, pp. e168-9, 2009 (PubMed).

Levy, Ehret, Rice et al.: "Genome-wide association study of blood pressure and hypertension. ..." in: Nature genetics, Vol. 41, Issue 6, pp. 677-87, 2010 (PubMed).