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Details for Product No. ABIN969072

Catenin beta-1 (CTNB1) antibody

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Antigen
Synonyms Bfc, Catnb, Mesc, ctnnb, id:ibd2058, wu:fb73e10, wu:fi81c06, wu:fk25h01, CHBCAT
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Fluorescence Microscopy (FM)
Pubmed 3 references available
Catalog no. ABIN969072
Quantity 100 µL
Price
363.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 3 to 4 Business Days
Immunogen Purified recombinant fragment of human CTNNB1 expressed in E. coli.
Clone 4D5
Isotype IgG1
Purification Ascites
Alternative Name CTNNB1
Background Synonyms:
CTNNB, FLJ25606, FLJ37923, DKFZp686D02253, CTNNB1
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. The distinct peripheral cytosolic proteins, α, β and γ catenin (102, 94 and 86 kDa) are found in many tissues and bind to the conserved cytoplasmic tail domain of the cell adhesion cadherins. Catenins link E cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt1 proto oncogene. The central core region of β catenin is involved in mediation of cadherin catenin complex interaction with EGFR. β-Catenin-mediated signalling is involved at several stages of vertebrate neural development.
Molecular Weight 85 kDa
Gene ID 1499
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Product cited in: Rubinfeld, Souza, Albert et al.: "The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin." in: The Journal of biological chemistry, Vol. 270, Issue 10, pp. 5549-55, 1995 (PubMed).

Guo, Liu, Yang et al.: "Relation among p130Cas, E-cadherin and beta-catenin expression, clinicopathologic significance and prognosis in human hepatocellular carcinoma." in: Hepatobiliary & pancreatic diseases international : HBPD INT, Vol. 7, Issue 5, pp. 490-6, 2008 (PubMed).

Bougatef, Ouerhani, Moussa et al.: "Prevalence of mutations in APC, CTNNB1, and BRAF in Tunisian patients with sporadic colorectal cancer." in: Cancer genetics and cytogenetics, Vol. 187, Issue 1, pp. 12-8, 2008 (PubMed).

Alternatives for antigen "Catenin beta-1 (CTNB1)", type "Antibodies"
Hosts (462), (147), (2), (1)
Reactivities (573), (324), (305), (192), (161), (117), (14), (8), (6), (6), (4), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Applications (446), (172), (151), (140), (117), (96), (70), (54), (40), (22), (8), (5), (3), (1), (1), (1)
Conjugates (19), (16), (16), (15), (14), (14), (14), (14), (14), (14), (14), (1), (1)
Epitopes (55), (53), (49), (43), (43), (28), (20), (16), (15), (15), (13), (12), (9), (7), (7), (5), (5), (5), (4), (4), (4), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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