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PERK antibody

EIF2AK3 Reactivity: Human ELISA, WB Host: Mouse Monoclonal 5G5 unconjugated
Catalog No. ABIN969093
  • Target See all PERK (EIF2AK3) Antibodies
    PERK (EIF2AK3) (Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3))
    Reactivity
    • 120
    • 75
    • 73
    • 16
    • 16
    Human
    Host
    • 113
    • 4
    • 3
    • 1
    Mouse
    Clonality
    • 116
    • 5
    Monoclonal
    Conjugate
    • 44
    • 12
    • 9
    • 6
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    This PERK antibody is un-conjugated
    Application
    • 81
    • 57
    • 45
    • 28
    • 26
    • 26
    • 14
    • 10
    • 8
    • 6
    • 6
    • 4
    • 2
    • 1
    ELISA, Western Blotting (WB)
    Purification
    purified
    Immunogen
    Purified recombinant fragment of human EIF2AK3 expressed in E. coli.
    Clone
    5G5
    Isotype
    IgG1
    Top Product
    Discover our top product EIF2AK3 Primary Antibody
  • Application Notes
    ELISA: 1:10000, WB: 1:500 - 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    4°C, -20°C for long term storage
  • Yamaguchi, Larkin, Lara-Lemus, Ramos-Castañeda, Liu, Arvan: "Endoplasmic reticulum (ER) chaperone regulation and survival of cells compensating for deficiency in the ER stress response kinase, PERK." in: The Journal of biological chemistry, Vol. 283, Issue 25, pp. 17020-9, (2008) (PubMed).

    Liang, Yang, Wang, Li, Tang, Chen: "Polycystin-2 down-regulates cell proliferation via promoting PERK-dependent phosphorylation of eIF2alpha." in: Human molecular genetics, Vol. 17, Issue 20, pp. 3254-62, (2008) (PubMed).

  • Target
    PERK (EIF2AK3) (Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3))
    Alternative Name
    EIF2AK3 (EIF2AK3 Products)
    Synonyms
    EIF2AK3 antibody, AI427929 antibody, Pek antibody, Perk antibody, PEK antibody, PERK antibody, WRS antibody, eukaryotic translation initiation factor 2 alpha kinase 3 antibody, EIF2AK3 antibody, Eif2ak3 antibody
    Background

    Description: The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.

    Aliases: PEK, WRS, PERK, EIF2AK3

    Molecular Weight
    125 kDa
    Gene ID
    9451
    HGNC
    9451
    Pathways
    Hormone Transport, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Unfolded Protein Response
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