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Fibulin 5 antibody (FBLN5) (AA 242-448)

Details for Product anti-FBLN5 Antibody No. ABIN969131, Supplier: Log in to see
Antigen
  • A55
  • ADCL2
  • ARCL1A
  • ARMD3
  • DANCE
  • DKFZp469K0327
  • EVEC
  • FBLN5
  • FIBL-5
  • Fibulin-5
  • MGC108414
  • UP50
  • zgc:103575
Epitope
AA 242-448
31
15
13
7
5
5
5
5
4
3
2
2
1
1
Reactivity
Human
111
42
34
5
4
2
2
2
1
1
Host
Mouse
78
32
15
Clonality (Clone)
Monoclonal ()
Conjugate
This Fibulin 5 antibody is un-conjugated
9
8
4
3
3
3
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
101
81
29
15
11
7
6
3
2
1
Supplier
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Immunogen Purified recombinant fragment of FBLN5 (AA 242-448) expressed in E. coli.
Clone 1G6A4
Isotype IgG1
Purification Ascites
Alternative Name FBLN5 (FBLN5 Antibody Abstract)
Background FBLN5: fibulin 5. The protein is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling.
Gene ID 10516
HGNC 10516
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
Immunohistochemistry (IHC) image for anti-Fibulin 5 antibody (FBLN5) (AA 242-448) (ABIN969131) Figure 1: Immunohistochemical analysis of paraffin-embedded human colon cancer (left)...
Western Blotting (WB) image for anti-Fibulin 5 antibody (FBLN5) (AA 242-448) (ABIN969131) Figure 2: Western blot analysis using FBLN5 mouse mAb against truncated FBLN5-His rec...
Product cited in: Wang, LeMaire, Chen, Carter, Shen, Gan, Bartsch, Wilks, Utama, Ou, Thompson, Coselli, Wang: "Decreased expression of fibulin-5 correlates with reduced elastin in thoracic aortic dissection." in: Surgery, Vol. 138, Issue 2, pp. 352-9, 2005

Stone, Braun, Russell, Kuehn, Lotery, Moore, Eastman, Casavant, Sheffield: "Missense variations in the fibulin 5 gene and age-related macular degeneration." in: The New England journal of medicine, Vol. 351, Issue 4, pp. 346-53, 2004

Markova, Zou, Ringpfeil, Sasaki, Kostka, Timpl, Uitto, Chu: "Genetic heterogeneity of cutis laxa: a heterozygous tandem duplication within the fibulin-5 (FBLN5) gene." in: American journal of human genetics, Vol. 72, Issue 4, pp. 998-1004, 2003

Background publications Clark, Gurney, Abaya, Baker, Baldwin, Brush, Chen, Chow, Chui, Crowley, Currell, Deuel, Dowd, Eaton, Foster, Grimaldi, Gu, Hass, Heldens, Huang, Kim, Klimowski, Jin, Johnson, Lee, Lewis, Liao, Mark et al.: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ..." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, 2003