FCER2 antibody

Catalog No. ABIN969132

Product Details anti-FCER2 Antibody

Target: FCER2 (Fc Fragment of IgE, Low Affinity II, Receptor For (CD23) (FCER2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FCER2 antibody is un-conjugated

Application: Flow Cytometry (FACS), ELISA

Purification: purified

Immunogen: Purified recombinant fragment of human FCER2 expressed in E. coli.

Clone: 5B5

Isotype: IgG1

Application Details

Application Notes: ELISA: 1:10000, FCM: 1:200 - 1:400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

References for anti-FCER2 antibody (ABIN969132)

Carvalho, Fullen, Lowe, Su, Ma: "Comparison of CD23 staining patterns in Merkel cell carcinoma and non-cutaneous small cell carcinoma." in: Journal of cutaneous pathology, Vol. 36, Issue 2, pp. 206-10, (2009) (PubMed).

Shen, Vermeulen, Rajaraman, Menashe, He, Chapman, Yeager, Thomas, Burdett, Hutchinson, Yuenger, Chanock, Lan: "Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China." in: Environmental and molecular mutagenesis, Vol. 50, Issue 4, pp. 285-90, (2009) (PubMed).

Target Details for FCER2

Target: FCER2 (Fc Fragment of IgE, Low Affinity II, Receptor For (CD23) (FCER2))

Alternative Name: FCER2 (FCER2 Products)

Synonyms: BLAST-2 antibody, CD23 antibody, CD23A antibody, CLEC4J antibody, FCE2 antibody, IGEBF antibody, Fcer2a antibody, Fc fragment of IgE receptor II antibody, FCER2 antibody, Fcer2 antibody

Background:

Description: The human leukocyte differentiation antigen CD23 (FCE2) is a key molecule for B-cell activation and growth. It is the low-affinity receptor for IgE. The truncated molecule can be secreted, then functioning as a potent mitogenic growth factor.(supplied by OMIM) . It is expressed on most mature, conventional B cells (but not on peritoneal CD5+ B cells), and can also be found on the surface of T cells, macrophages, platelets and EBV transformed B lymphoblasts. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic Lymphocytic leukemia. CD23 is expressed by B cells in the follicular mantle but not by proliferating germinal centre cells. CD23 is also expressed by eosinophils. CD23 is distinct from the high affinity IgE receptors found on basophils and mast cells, which mediate allergic reactions. The low affinity receptors are thought to play a role in isotype specific immunoregulation. The regulation of CD23 surface expression appears to be integral with the complex IgE system, which involves interactions of cells, cytokines, antibodies and regulatory factors. CD23 has been described as a ""membrane bound cytokine," in that the soluble cleavage products of CD23 are themselves able to act as cytokines in vitro.

Aliases: CD23, FCE2, CD23A, IGEBF, CLEC4J, FCER2

Molecular Weight: 37 kDa

Gene ID: 2208

HGNC: 2208

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process