Fibulin 5 antibody (FBLN5)

Details for Product anti-FBLN5 Antibody No. ABIN969144, Supplier: Log in to see
Antigen
  • zgc:103575
  • FBLN5
  • MGC108414
  • Fibulin-5
  • DKFZp469K0327
  • ADCL2
  • ARCL1A
  • ARMD3
  • DANCE
  • EVEC
  • FIBL-5
  • UP50
  • A55
  • fibulin 5
  • Fibulin 5
  • fbln5
  • FBLN5
  • LOC100222931
  • Fbln5
  • LOC100155248
Reactivity
Human
123
45
36
4
3
1
1
1
1
1
Host
Mouse
83
38
16
Clonality (Clone)
Monoclonal ()
Conjugate
This Fibulin 5 antibody is un-conjugated
9
8
4
3
3
3
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
119
94
40
16
13
6
4
4
3
2
1
1
Options
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Immunogen Purified recombinant fragment of Fibulin 5 expressed in E. Coli.
Clone 3F10A5
Isotype IgG1
Purification Ascites
Alternative Name Fibulin 5 (FBLN5 Antibody Abstract)
Background Fibulin 5(FBLN5), with 448-amino acid protein (about 50 kDa), is a recently discovered multifunctional extracellular matrix protein that mediates endothelial cell adhesion through integrin ligation, regulates cell growth and motility in a context-specific manner, and prevents elastinopathy in vivo. Fibulin-5 is abundantly expressed in great vessels and cardiac valves during embryogenesis, and in many adult tissues including the aorta, lung, uterus and skin, all of which contain abundant elastic fibres. Decreased fibulin-5 may contribute to the pathogenesis of aortic dissection by impairing elastic fiber assembly. Fibulin-5 is also a good marker of skin ageing and that the earlier loss of fibulin-5 may involve age-dependent changes in other elastic fibre components.
Gene ID 10516
HGNC 10516
Research Area Cardiovascular, Atherosclerosis, Extracellular Matrix
Application Notes ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage
Supplier Images
Immunohistochemistry (IHC) image for anti-Fibulin 5 antibody (FBLN5) (ABIN969144) Figure 1: Immunohistochemical analysis of paraffin-embedded human stomach carcinoma (...
Western Blotting (WB) image for anti-Fibulin 5 antibody (FBLN5) (ABIN969144) Figure 2: Western blot analysis using Fibulin5 mouse mAb against truncated fibulin5 r...
Product cited in: Wen, Hochholdinger, Sauer, Bruce, Schnable: "The roothairless1 gene of maize encodes a homolog of sec3, which is involved in polar exocytosis." in: Plant physiology, Vol. 138, Issue 3, pp. 1637-43, 2005 (PubMed).

Kadoya, Sasaki, Kostka, Timpl, Matsuzaki, Kumagai, Sakai, Nishiyama, Amano: "Fibulin-5 deposition in human skin: decrease with ageing and ultraviolet B exposure and increase in solar elastosis." in: The British journal of dermatology, Vol. 153, Issue 3, pp. 607-12, 2005 (PubMed).

Wang, LeMaire, Chen, Carter, Shen, Gan, Bartsch, Wilks, Utama, Ou, Thompson, Coselli, Wang: "Decreased expression of fibulin-5 correlates with reduced elastin in thoracic aortic dissection." in: Surgery, Vol. 138, Issue 2, pp. 352-9, 2005 (PubMed).

Lee, Roy, Mogford, Schiemann, Mustoe: "Fibulin-5 promotes wound healing in vivo." in: Journal of the American College of Surgeons, Vol. 199, Issue 3, pp. 403-10, 2004 (PubMed).