Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) antibody

Details for Product No. ABIN969186
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Antigen
Synonyms CG1490, Dmel\\CG1490, USP7, 2210010O09Rik, AA409944, AA617399, AU019296, AW548146, C80752, Hausp, HAUSP, TEF1, UBP
Reactivity
Human
(79), (19), (19), (15), (14), (14), (12), (1), (1), (1), (1), (1)
Host
Mouse
(58), (22), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(69), (34), (20), (13), (10), (10), (6), (2), (2), (1), (1)
Pubmed 2 references available
Quantity 100 μL
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Catalog No. ABIN969186
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Immunogen Purified recombinant fragment of human HAUSP expressed in E. coli.
Clone 5F11
Isotype IgG1
Purification Ascites
Alternative Name HAUSP
Background Synonyms:
TEF1, HAUSP, USP7
USP7 or HAUSP is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. Since ubiquitylation (polyubiquitination) is most commonly associated with the stability and degradation of cellular proteins, HAUSP acitivity generally stabilizes its substrate proteins. HAUSP is most popularly known as a direct antagonist of Mdm2, the E3 ubiquitin ligase for the tumor suppressor protein, p53. Normally, p53 levels are kept low in part due to Mdm2-mediated ubiquitylation and degradation of p53. Interestingly, in response to oncogenic insults, HAUSP can deubiquitinate p53 and protect p53 from Mdm2-mediated degradation, indicating that it may possess a tumor suppressor function for the immediate stabilization of p53 in response to stress. Another important role of HAUSP function involves the oncogenic stabilization of p53. Oncogenes such as Myc and E1A are thought to activate p53 through a p19 alternative reading frame (p19ARF, also called ARF) -dependent pathway, although some evidence suggests ARF is not essential in this process. An intriguing possibility is that HAUSP provides an alternative pathway for safeguarding the cell against oncogenic insults.
Molecular Weight 128 kDa
Gene ID 7874
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
anti-Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) antibody Figure 1: Western blot analysis using HAUSP mouse mAb against MCF-7 (1) cell lysate.
Product cited in: Becker, Marchenko, Maurice et al.: "Hyperubiquitylation of wild-type p53 contributes to cytoplasmic sequestration in neuroblastoma." in: Cell death and differentiation, Vol. 14, Issue 7, pp. 1350-60, 2007 (PubMed).

Daubeuf, Singh, Tan et al.: "HSV ICP0 recruits USP7 to modulate TLR-mediated innate response." in: Blood, Vol. 113, Issue 14, pp. 3264-75, 2009 (PubMed).

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