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Inhibin alpha antibody

INHA Reactivity: Human, Mouse WB, ELISA, ICC Host: Mouse Monoclonal 4-00E-02 unconjugated
Catalog No. ABIN969217
  • Target See all Inhibin alpha (INHA) Antibodies
    Inhibin alpha (INHA) (Inhibin, alpha (INHA))
    Reactivity
    • 77
    • 63
    • 54
    • 25
    • 10
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Human, Mouse
    Host
    • 109
    • 21
    • 2
    Mouse
    Clonality
    • 110
    • 23
    Monoclonal
    Conjugate
    • 62
    • 21
    • 18
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This Inhibin alpha antibody is un-conjugated
    Application
    • 106
    • 61
    • 48
    • 26
    • 26
    • 22
    • 17
    • 12
    • 11
    • 8
    • 8
    • 7
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunocytochemistry (ICC)
    Purification
    purified
    Immunogen
    Purified recombinant fragment of human INHA expressed in E. coli.
    Clone
    4-00E-02
    Isotype
    IgG1
    Top Product
    Discover our top product INHA Primary Antibody
  • Application Notes
    ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: 1:200 - 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    4°C, -20°C for long term storage
  • Makovitzky, Radtke, Shabani, Friese, Gerber, Mylonas: "Invasive hydatidiform mole: immunohistochemical labelling of inhibin/activin subunits, Ki67, p53 and glycodelin A in a rare case." in: Acta histochemica, Vol. 111, Issue 4, pp. 360-5, (2009) (PubMed).

    Corre, Schuettler, Bione, Marozzi, Persani, Rossetti, Torricelli, Giotti, Vogt, Toniolo: "A large-scale association study to assess the impact of known variants of the human INHA gene on premature ovarian failure." in: Human reproduction (Oxford, England), Vol. 24, Issue 8, pp. 2023-8, (2009) (PubMed).

    Palmieri, Wilson, Iversen, Clyde, Calingaert, Moorman, Poole, Anderson, Anderson, Anton-Culver, Beesley, Hogdall, Brewster, Carney, Chen, Chenevix-Trench, Chang-Claude, Cunningham, Dicioccio, Doherty et al.: "Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. ..." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 17, Issue 12, pp. 3567-72, (2008) (PubMed).

  • Target
    Inhibin alpha (INHA) (Inhibin, alpha (INHA))
    Alternative Name
    INHA (INHA Products)
    Synonyms
    si:dkey-91f15.2 antibody, INHA antibody, MGC108500 antibody, AW555078 antibody, inhibin, alpha antibody, inhibin alpha subunit antibody, inhibin alpha antibody, inhibin alpha L homeolog antibody, inha antibody, INHA antibody, inha.L antibody, Inha antibody
    Background

    Description: Inhibins are peptide hormones produced by the granulosa cells in female follicles and by Sertoli cells in the male seminiferous tubules. They are selectively expressed by cells of sex cord stromal derivation, and inhibit the secretion of follitropin by the pituitary gland. Inhibins are also involved in regulating diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins, as inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibin has 2 subunits (alpha and beta) that are coded by separate genes. The alpha subunit determines whether inhibin or activin will be produced. The alpha subunit remains constant, such that the various types of inhibin are defined by the beta subunit (a,b,c,d). Inhibin A is a dimer of alpha and beta A. Inhibin B is a dimer of alpha and beta B. Proteolytic processing yields a number of inhibin alpha bioactive forms: the 20/23 kDa forms consist solely of the mature alpha chain, the 26/29 kDa forms consist of the most N terminal propeptide linked through a disulfide bond to the mature alpha chain, and the 50/53 kDa forms encompass the entire proprotein. Each type can be furthermore either mono or diglycosylated, causing the mass difference.

    Aliases: INHA

    Molecular Weight
    40 kDa
    Gene ID
    3623
    HGNC
    3623
    Pathways
    Peptide Hormone Metabolism, Hormone Activity, Negative Regulation of Hormone Secretion
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