JAK2 antibody (Janus Kinase 2) (AA 745-955)

Details for Product anti-JAK2 Antibody No. ABIN969223, Supplier: Log in to see
Antigen
  • JAK2bCA
  • jak2
  • JTK10
  • THCYT3
  • AI504024
  • C81284
  • Fd17
  • JAK-2
  • Janus kinase 2b
  • Janus kinase 2
  • tyrosine-protein kinase JAK2-like
  • jak2b
  • JAK2
  • Jak2
  • LOC100051487
Alternatives
anti-Human JAK2 antibody for ELISA
Epitope
AA 745-955
46
27
19
16
15
13
11
10
10
8
8
7
7
4
4
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
258
161
149
8
6
6
6
2
1
1
Host
Mouse
250
20
4
Clonality (Clone)
Monoclonal ()
Conjugate
This JAK2 antibody is un-conjugated
11
8
6
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
Application
ELISA, Western Blotting (WB)
181
120
99
27
27
25
20
15
12
9
7
3
2
Options
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Immunogen Purified recombinant fragment of JAK2(745-955aa) expressed in E. Coli.
Clone 1C1
Isotype IgG1
Purification Ascites
Alternative Name JAK2 (JAK2 Antibody Abstract)
Background This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.
Molecular Weight 130.6 kDa
Gene ID 3717
HGNC 3717
Research Area Signaling, Cytokines, Receptors, Kinases/Phosphatases
Pathways JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Response to Growth Hormone Stimulus, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling
Application Notes ELISA: 1:10000, WB: 1:500 - 1:2000
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage
Supplier Images
Western Blotting (WB) image for anti-JAK2 antibody (Janus Kinase 2) (AA 745-955) (ABIN969223) Figure 1: Western blot analysis using JAK2 mouse mAb against THP-1 (1) cell lysate.
Product cited in: Hermanns, Radtke, Haan, Schmitz-Van de Leur, Tavernier, Heinrich, Behrmann: "Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 12, pp. 6651-8, 2000 (PubMed).

Background publications Pollack, Kotenko, He, Izotova, Barnoski, Pestka: "The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity." in: The Journal of biological chemistry, Vol. 274, Issue 44, pp. 31531-42, 1999 (PubMed).

Pezet, Buteau, Kelly, Edery: "The last proline of Box 1 is essential for association with JAK2 and functional activation of the prolactin receptor." in: Molecular and cellular endocrinology, Vol. 129, Issue 2, pp. 199-208, 1997 (PubMed).