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JAK2 antibody (Janus Kinase 2) (AA 745-955)

Details for Product anti-JAK2 Antibody No. ABIN969223, Supplier: Log in to see
Antigen
  • AI504024
  • C81284
  • Fd17
  • JAK-2
  • jak2
  • JAK2bCA
  • JTK10
  • THCYT3
Alternatives
anti-Human JAK2 antibody for Western Blotting
Epitope
AA 745-955
47
27
19
17
14
12
11
11
9
8
8
7
5
4
4
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
248
164
153
8
7
6
6
2
1
1
1
Host
Mouse
240
18
5
Clonality (Clone)
Monoclonal ()
Conjugate
This JAK2 antibody is un-conjugated
9
6
6
4
2
2
2
2
2
2
2
2
2
2
2
Application
ELISA, Western Blotting (WB)
173
112
101
30
26
25
17
11
5
4
3
3
Supplier
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Immunogen Purified recombinant fragment of JAK2 (745-955AA ) expressed in E. coli.
Clone 1C1
Isotype IgG1
Purification Ascites
Alternative Name JAK2 (JAK2 Antibody Abstract)
Background This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.
Molecular Weight 130.6 kDa
Gene ID 3717
HGNC 3717
Research Area Signaling, Cytokines, Receptors, Kinases/Phosphatases
Pathways JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
Western Blotting (WB) image for anti-JAK2 antibody (Janus Kinase 2) (AA 745-955) (ABIN969223) Figure 1: Western blot analysis using JAK2 mouse mAb against THP-1 (1) cell lysate.
Product cited in: Hermanns, Radtke, Haan, Schmitz-Van de Leur, Tavernier, Heinrich, Behrmann: "Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 12, pp. 6651-8, 2000 (PubMed).

Background publications Pollack, Kotenko, He, Izotova, Barnoski, Pestka: "The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity." in: The Journal of biological chemistry, Vol. 274, Issue 44, pp. 31531-42, 1999 (PubMed).

Pezet, Buteau, Kelly, Edery: "The last proline of Box 1 is essential for association with JAK2 and functional activation of the prolactin receptor." in: Molecular and cellular endocrinology, Vol. 129, Issue 2, pp. 199-208, 1997 (PubMed).