Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) (AA 20-764) antibody

Details for Product No. ABIN969231
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Antigen
Synonyms
vegfr-2, KDR, 6130401C07, Flk-1, Flk1, Krd-1, Ly73, VEGFR-2, VEGFR2, sVEGFR-2, Vegfr-2, CD309, FLK1, VEGFR, FLK-1, flk-1, FLK/KDR, flk1, flk1b, kdrb, si:busm1-205d10.1, si:ch211-254j6.1, si:ch211-278f ... show more
vegfr-2, KDR, 6130401C07, Flk-1, Flk1, Krd-1, Ly73, VEGFR-2, VEGFR2, sVEGFR-2, Vegfr-2, CD309, FLK1, VEGFR, FLK-1, flk-1, FLK/KDR, flk1, flk1b, kdrb, si:busm1-205d10.1, si:ch211-254j6.1, si:ch211-278f21.4, wu:fc31a09, fk52c05, flk, kdr, kdra, vegfr2, vegfr4, vegr2, wu:fk52c05 show less
Epitope
AA 20-764
(60), (47), (41), (40), (29), (23), (17), (16), (15), (13), (10), (9), (8), (7), (6), (6), (6), (6), (5), (5), (5), (5), (4), (4), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(489), (291), (186), (64), (61), (53), (49), (26), (4), (2), (2), (2), (2), (2), (2), (2), (1)
Host
Mouse
(452), (73), (35), (3), (2), (2), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(33), (15), (12), (10), (9), (6), (6), (6), (6), (6), (6), (6), (6), (6), (3), (3), (3), (3), (2), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB), Immunocytochemistry (ICC), Fluorescence Microscopy (FM)
(387), (175), (174), (122), (88), (85), (60), (56), (32), (24), (10), (7), (7), (4), (3), (1)
Pubmed 1 reference available
Quantity 100 μL
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Catalog No. ABIN969231
363.00 $
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Immunogen Purified recombinant extracellular fragment of human KDR (AA 20-764) fused with hIgGFc tag expressed in HEK293 cells.
Clone 4B4
Isotype IgG1
Purification Ascites
Alternative Name KDR
Background Synonyms:
FLK1, CD309, VEGFR, VEGFR2
kDaR has also been designated as VEFR-2 (Vascular endothelial growth factor receptor 2), CD309 (cluster of differentiation 309) and Flk1 (fηl liver kinase 1). Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. kDaR is one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin αVβ3, T-cell protein tyrosine phosphatase, etc. . Mutations of this gene are implicated in infantile capillary hemangiomas.
Molecular Weight 152 kDa
Gene ID 3791
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
anti-Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) (AA 20-764) antibody Figure 3: Flow cytometric analysis of HepG2 cells using KDR mouse mAb (green) and negative control (purple) .
anti-Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) (AA 20-764) antibody (2) Figure 2: Confocal immunofluorescence analysis of Hela (left) and HepG2 (right) cells using KDR mouse mAb (green) . Blue: DRAQ5 fluorescent DNA dye.
anti-Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) (AA 20-764) antibody (3) Figure 1: Western blot analysis using KDR mouse mAb against extracellular domain of human KDR (aa20-764) .
Product cited in: Lee, Bone, Strege et al.: "VEGF receptor phosphorylation status and apoptosis is modulated by a green tea component, epigallocatechin-3-gallate (EGCG), in B-cell chronic lymphocytic leukemia." in: Blood, Vol. 104, Issue 3, pp. 788-94, 2004 (PubMed).

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