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Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) (AA 20-764) antibody

Antigen

Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR)
Synonyms Flk1, Ly73, Flk-1, Krd-1, VEGFR2, VEGFR-2, sVEGFR-2, 6130401C07, FLK1, CD309, VEGFR, Vegfr-2, MGC93590, KDR, FLK-1, flk-1, vegfr-2
Binding Site
Alternatives

AA 20-764
Clonality Monoclonal (4B4)
Host
Alternatives

Mouse
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Western Blotting (WB)
1 reference available
Catalog no. ABIN969231
Quantity 0.1ml
Price 363.00 $   Plus shipping costs $45.00
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Additional Information
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Alternative name KDR
Gene ID 3791
Immunogen Purified recombinant extracellular fragment of human KDR (AA 20-764) fused with hIgGFc tag expressed in HEK293 cells.
Format Liquid
Isotype IgG1
Clone 4B4
Description KDR has also been designated as VEFR-2 (Vascular endothelial growth factor receptor 2), CD309 (cluster of differentiation 309) and Flk1 (fetal liver kinase 1). Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. KDR is one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc. Mutations of this gene are implicated in infantile capillary hemangiomas.
Synonyms: FLK1, CD309, VEGFR, VEGFR2
Molecular Weight 152kDa

Application Details
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Application Notes Western Blotting: 1/500 - 1/2000.
Immunofluorescence: 1/200 - 1/1000.
Flow cytometry: 1/200 - 1/400.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Purification Ascites
Buffer Ascitic fluid containing 0.03% sodium azide.
Preservative 0.03% sodium azide
Storage Store at 4℃, for long term storage, store at -20℃.
Restrictions For Research Use only

Publications
Application Details Alternatives back to top

Product Lee, Bone, Strege et al.: "VEGF receptor phosphorylation status and apoptosis is modulated by a green tea component, epigallocatechin-3-gallate (EGCG), in B-cell chronic lymphocytic leukemia." in: Blood, Vol. 104, Issue 3, pp. 788-94, 2004 (PubMed).

Alternatives
Application Details Publications back to top

Alternatives for antigen "Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR)", type "Antibodies"
Hosts Rabbit (177), Mouse (28), Rat (15), Escherichia Coli (E. coli) (2), Goat (2), Chicken (1)
Reactivities Human (180), Mouse (Murine) (124), Rat (Rattus) (93), Dog (Canine) (20), Chicken (19), Cow (Bovine) (19), Pig (Porcine) (18), Cat (Feline) (1)
Applications Western Blotting (WB) (142), Immunohistochemistry (IHC) (87), ELISA (72), Immunofluorescence (IF) (67), Flow Cytometry (FACS) (61), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (30), Immunoprecipitation (IP) (16), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (8), Immunocytochemistry (ICC) (5), Neutralization (Neut) (5), Immunohistochemistry (Frozen Sections) (IHC (fro)) (3), Immunoelectron Microscopy (IEM) (2), Immunohistochemistry (Fixed) (IHC (fx)) (2), Dot Blot (DB) (1), Dot Blot (Dot) (1)
Conjugates Biotin (11), PE (5), FITC (3), APC (2), Alexa Fluor 350 (2), Alexa Fluor 488 (2), Alexa Fluor 555 (2), Alexa Fluor 647 (2), Cy3 (2), Cy5 (2), Cy5.5 (2), Cy7 (2), Gold (2), HRP (2), PE,Cy3 (2), PE,Cy5 (2), PE,Cy5.5 (2), PE,Cy7 (2), E-Tag (1)
Epitopes pTyr951 (31), N-Term (20), C-Term (16), pTyr1175 (12), pTyr1214 (10), Internal Region (5), Extracellular Domain (4), Tyr1175 (3), Tyr1214 (3), Tyr951 (3), pTyr1054 (3), pTyr1059 (3), pTyr996 (3), AA 1158-1345 (2), AA 1160-1190 (2), pY1054 (2), AA 20-762 (1), AA 20-764 (1), C-Term,AA 919-949 (1), Extracellular,AA 20-764 (1), pTyr1054, pTyr1059 (1), pY951 (1)