KSHVORF62 antibody

Catalog No. ABIN969255

Product Details

Target: KSHVORF62

Reactivity: Human Herpesvirus 8 (HHV-8)

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: purified

Immunogen: Purified recombinant fragment of human KSHV ORF62 expressed in E. coli.

Clone: 5B7B6

Isotype: IgM

Application Details

Application Notes: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

References

Holyfield: "Spit Tobacco Prevention Network (STOPN)." in: Texas nursing, Vol. 74, Issue 10, pp. 9, (2002) (PubMed).

Wu, Lo, Yu, Stoops, Forghani, Zhou: "Three-dimensional structure of the human herpesvirus 8 capsid." in: Journal of virology, Vol. 74, Issue 20, pp. 9646-54, (2000) (PubMed).

Nakamura, Oguri, Tabe, Igari: "[Epidemiological study on Staphylococcus epidermidis isolated from bloodstream and blood vessel catheter]." in: Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases, Vol. 74, Issue 2, pp. 96-103, (2000) (PubMed).

Target Details

Target: KSHVORF62

Target Type: Viral Protein

Background:

Description: Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. At least five major proteins are likely to be involved in the assembly of the HHV-8 capsid, including a protease (encoded by ORF17), the major capsid protein (encoded by ORF25), and three other smaller capsid proteins (encoded by ORF62, ORF26, and ORF65). Previous structural studies have shown that the HSV-1 triplex is a monomer of VP19c and a dimer of VP23 and that the HCMV triplex is similarly composed of a monomer and a dimer. By analogy, the KSHV triplexes are likely also composed of a monomer of the ORF62 protein and a dimer of the ORF26 protein, which are the respective homologs of VP19c and VP23.

Aliases: ORF62

Gene ID: 4961461

HGNC: 4961461