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KSHV ORF62 antibody
Kaposi's Sarcoma-associated Herpesvirus (KSHV)
Alternatives ELISA, Immunofluorescence (IF), Western Blotting (WB)
|5 references available|
|Price||319.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 3 to 4 Business Days|
|Immunogen||Purified recombinant fragment of human KSHV ORF62 expressed in E. Coli.|
Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi’s sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman’s disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. At least five major proteins are likely to be involved in the assembly of the HHV-8 capsid, including a protease (encoded by ORF17), the major capsid protein (encoded by ORF25), and three other smaller capsid proteins (encoded by ORF62, ORF26, and ORF65). Previous structural studies have shown that the HSV-1 triplex is a monomer of VP19c and a dimer of VP23 and that the HCMV triplex is similarly composed of a monomer and a dimer. By analogy, the KSHV triplexes are likely also composed of a monomer of the ORF62 protein and a dimer of the ORF26 protein, which are the respective homologs of VP19c and VP23.
Western Blotting: 1/500 - 1/2000.
Immunofluorescence: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
|Buffer||Ascitic fluid containing 0.03% sodium azide.|
|Preservative||0.03% sodium azide|
|Storage||Store at 4℃, for long term storage, store at -20℃.|
|Restrictions||For Research Use only|
Chang, Cesarman, Pessin et al.: "Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma." in: Science (New York, N.Y.), Vol. 266, Issue 5192, pp. 1865-9, 1995 (PubMed).
Russo, Bohenzky, Chien et al.: "Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 25, pp. 14862-7, 1997 (PubMed).
Nakamura, Oguri, Tabe et al.: "[Epidemiological study on Staphylococcus epidermidis isolated from bloodstream and blood vessel catheter]." in: Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases, Vol. 74, Issue 2, pp. 96-103, 2000 (PubMed).
Wu, Lo, Yu et al.: "Three-dimensional structure of the human herpesvirus 8 capsid." in: Journal of virology, Vol. 74, Issue 20, pp. 9646-54, 2000 (PubMed).
Holyfield: "Spit Tobacco Prevention Network (STOPN)." in: Texas nursing, Vol. 74, Issue 10, pp. 9, 2002 (PubMed).
|Reactivities||Kaposi's Sarcoma-associated Herpesvirus (KSHV) (2)|
|Applications||ELISA (4), Western Blotting (WB) (4), Immunocytochemistry (ICC) (2), Immunofluorescence (IF) (1)|