LSD1 antibody

Catalog No. ABIN969264

Product Details anti-LSD1 Antibody

Target: LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))

Reactivity: Human, Mouse, Monkey

Host: Mouse

Clonality: Monoclonal

Conjugate: This LSD1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: purified

Immunogen: Purified recombinant fragment of human LSD1 expressed in E. coli.

Clone: 1B2E5

Isotype: IgG1

Application Details

Application Notes: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

References for anti-LSD1 antibody (ABIN969264)

Shi, Matson, Lan, Iwase, Baba, Shi: "Regulation of LSD1 histone demethylase activity by its associated factors." in: Molecular cell, Vol. 19, Issue 6, pp. 857-64, (2005) (PubMed).

Metzger, Wissmann, Yin, Müller, Schneider, Peters, Günther, Buettner, Schüle: "LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription." in: Nature, Vol. 437, Issue 7057, pp. 436-9, (2005) (PubMed).

Target Details for LSD1

Target: LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))

Alternative Name: LSD1/AOF2 (KDM1A Products)

Synonyms: AOF2 antibody, BHC110 antibody, KDM1 antibody, LSD1 antibody, 1810043O07Rik antibody, AA408884 antibody, Aof2 antibody, D4Ertd478e antibody, Kdm1 antibody, Lsd1 antibody, mKIAA0601 antibody, DKFZp459N2450 antibody, RGD1562975 antibody, aof2 antibody, kdm1 antibody, wu:fb82e06 antibody, wu:fc51a02 antibody, wu:fj36a05 antibody, wu:fj66b06 antibody, KDM1A antibody, lsd1 antibody, xLSD1 antibody, AtLSD1 antibody, F9F13.30 antibody, F9F13_30 antibody, LESION SIMULATING DISEASE antibody, LESION SIMULATING DISEASE 1 antibody, lysine demethylase 1A antibody, lysine (K)-specific demethylase 1A antibody, lysine (K)-specific demethylase 1a antibody, LSD1 zinc finger family protein antibody, KDM1A antibody, Kdm1a antibody, kdm1a antibody, LSD1 antibody

Background:

Description: The amine oxidase domain 2 (AOF2) gene encodes a nuclear protein (LSD1, ~95 kDa) containing a Swirm domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. LSD1 is a chromatin-modifying enzyme, which serve as a docking module for the stabilization of the associated corepressor complex (es) on chromatin.

Aliases: KDM1, LSD1, AOF2

Molecular Weight: 93 kDa

Gene ID: 23028

HGNC: 23028

Pathways: Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Negative Regulation of intrinsic apoptotic Signaling, Warburg Effect