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NGFR antibody

NGFR Reactivity: Human WB, FACS, ELISA, ICC Host: Mouse Monoclonal 2F1C2 unconjugated
Catalog No. ABIN969315
  • Target See all NGFR Antibodies
    NGFR (Nerve Growth Factor Receptor (NGFR))
    Reactivity
    • 161
    • 61
    • 55
    • 29
    • 27
    • 26
    • 26
    • 21
    • 11
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 93
    • 75
    • 4
    • 1
    Mouse
    Clonality
    • 93
    • 80
    Monoclonal
    Conjugate
    • 91
    • 15
    • 12
    • 7
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NGFR antibody is un-conjugated
    Application
    • 106
    • 81
    • 61
    • 57
    • 47
    • 30
    • 27
    • 20
    • 19
    • 14
    • 14
    • 12
    • 9
    • 6
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunocytochemistry (ICC)
    Purification
    purified
    Immunogen
    Purified recombinant fragment of human NGFR expressed in E. coli.
    Clone
    2F1C2
    Isotype
    IgG1
    Top Product
    Discover our top product NGFR Primary Antibody
  • Application Notes
    ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    4°C, -20°C for long term storage
  • He, Garcia: "Structure of nerve growth factor complexed with the shared neurotrophin receptor p75." in: Science (New York, N.Y.), Vol. 304, Issue 5672, pp. 870-5, (2004) (PubMed).

    Hu, Zhang, Qin, Xu, Swaab, Zhou: "Increased p75(NTR) expression in hippocampal neurons containing hyperphosphorylated tau in Alzheimer patients." in: Experimental neurology, Vol. 178, Issue 1, pp. 104-11, (2002) (PubMed).

  • Target
    NGFR (Nerve Growth Factor Receptor (NGFR))
    Alternative Name
    NGFR (NGFR Products)
    Synonyms
    ngfr antibody, wu:fb38c02 antibody, wu:fc10h01 antibody, CD271 antibody, Gp80-LNGFR antibody, TNFRSF16 antibody, p75(NTR) antibody, p75NTR antibody, LNGFR antibody, RNNGFRR antibody, Tnfrsf16 antibody, p75 antibody, NRH1b antibody, fullback antibody, nrh1 antibody, p75ntr antibody, tnfrsf16 antibody, p75NGFR antibody, nerve growth factor receptor antibody, neurotrophin receptor associated death domain antibody, nerve growth factor receptor S homeolog antibody, nerve growth factor receptor (TNFR superfamily, member 16) antibody, NGFR antibody, nradd antibody, Ngfr antibody, ngfr.S antibody
    Background

    Description: Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. NGFR p75 plays a central role in the regulation of cell number by apoptosis in the developing CNS. During early development, activation of NGFR p75 by NGF induces apoptotic cell death in some neuronal cells, probably through activation of the sphingomyelinase/ceramide pathway, the ICE like proteases and the JNK pathway. In rat Schwann cells, NGF binding to NGFR p75 activates NF kappaB, possibly to modulate Schwann cell migration during nerve regeneration. CD271 has recently been described as being expressed in mesenchymal stem cells (bone marrow stromal cells).

    Aliases: CD271, p75NTR, TNFRSF16, p75(NTR), Gp80-LNGFR, NGFR

    Molecular Weight
    45 kDa
    Gene ID
    4804
    HGNC
    4804
    Pathways
    NF-kappaB Signaling, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding
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