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Details for Product No. ABIN969325

Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1) (AA 2-265) antibody

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Antigen
Synonyms B23, NPM, NO38, Npm, B23NP, CG7917, CRP1, Crp1, Dmel\\CG7917, dNLP, dNLP-S, p22, npm4, npm
Epitope
»Alternatives AA 2-265
Reactivity
»Alternatives Human, Monkey
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
Pubmed 2 references available
Catalog no. ABIN969325
Quantity 100 µL
Price
319.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 3 to 4 Business Days
Immunogen Purified recombinant fragment of human NPM (AA 2-265) expressed in E. coli.
Clone 7H10B9
Isotype IgG1
Purification Ascites
Alternative Name Nucleophosmin
Background Synonyms:
B23, NPM
Nucleophosmin (NPM), also named B23 or NO38, is a major nucleolar protein which is 20 times more abundant in tumor or proliferating cells than in normal resting cells. NPM has been implicated in several distinct cellular functions, including assembly and transport of ribosomes, cytoplasmic/nuclear trafficking, regulation of DNA polymerase α activity, centrosome duplication and molecular chaperoning activities. The NPM is also known for its fusion with the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. The NPM portion contributes to transformation by providing a dimerization domain, which results in activation of the fused kinase.
Molecular Weight 33 kDa
Gene ID 4869
Research Area Chromatin and Nuclear Signaling, DNA/RNA
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, ICC: 1/200 - 1/1000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Product cited in: Morris, Kirstein, Valentine et al.: "Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma." in: Science (New York, N.Y.), Vol. 263, Issue 5151, pp. 1281-4, 1994 (PubMed).

Yoneda-Kato, Look, Kirstein et al.: "The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1." in: Oncogene, Vol. 12, Issue 2, pp. 265-75, 1996 (PubMed).

Alternatives for antigen "Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1)", type "Antibodies"
Hosts (153), (52), (8)
Reactivities (195), (110), (109), (52), (49), (44), (18), (9), (6), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Applications (165), (96), (67), (55), (52), (40), (26), (23), (20), (4), (4), (2), (1), (1)
Conjugates (8), (6), (4), (4), (4), (4), (4), (4), (4), (4), (4), (2), (2), (1), (1)
Epitopes (30), (25), (17), (12), (12), (11), (6), (6), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
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