OLIG2 antibody

Catalog No. ABIN969331

Product Details anti-OLIG2 Antibody

Target: OLIG2 (Oligodendrocyte Lineage Transcription Factor 2 (OLIG2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This OLIG2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Purification: purified

Immunogen: Purified recombinant fragment of human OLIG2 expressed in E. coli.

Clone: 1G11

Isotype: IgG1

Application Details

Application Notes: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

References for anti-OLIG2 antibody (ABIN969331)

Bonnet-Dupeyron, Combes, Boespflug-Tanguy, Vaurs-Barrière: "Absence of OLIG2 mutations in patients presenting with a severe Pelizaeus-Merzbacher-like leukodystrophy associated with motor neuron dysfunction." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 147B, Issue 4, pp. 538-9, (2008) (PubMed).

Mikami, Hirose, Yoshida, Kawase, Ohnishi, Nagashima, Mukai, Okada, Ikeda: "Predominant expression of OLIG2 over ID2 in oligodendroglial tumors." in: Virchows Archiv : an international journal of pathology, Vol. 450, Issue 5, pp. 575-84, (2007) (PubMed).

Target Details for OLIG2

Target: OLIG2 (Oligodendrocyte Lineage Transcription Factor 2 (OLIG2))

Alternative Name: OLIG2 (OLIG2 Products)

Background:

Description: This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14,21)(q11.2,q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. Tissue specificity: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.

Aliases: BHLHB1, OLIGO2, RACK17, PRKCBP2, bHLHe19, OLIG2

Molecular Weight: 32 kDa

Gene ID: 10215

HGNC: 10215