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PAK2 antibody (P21-Activated Kinase 2)

Details for Product anti-PAK2 Antibody No. ABIN969338, Supplier: Log in to see
Antigen
  • pak2
  • cb422
  • kinase
  • zgc:91798
  • wu:fb71h01
  • si:dz198m22.1
  • pak65
  • pakgamma
  • PAK65
  • PAKgamma
  • 5330420P17Rik
  • A130002K10Rik
  • AI836325
  • D16Ertd269e
  • PAK-2
  • mKIAA4182
  • gamma-PAK
  • PAKI
  • Pak3
  • p21 (CDKN1A)-activated kinase 2a
  • p21 protein (Cdc42/Rac)-activated kinase 2
  • pak2a
  • pak2
  • PAK2
  • Pak2
Alternatives
anti-Human PAK2 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Reactivity
Human, Monkey
183
103
98
11
8
1
Host
Mouse
166
17
Clonality (Clone)
Monoclonal ()
Conjugate
This PAK2 antibody is un-conjugated
4
4
4
4
4
4
Application
Immunocytochemistry (ICC), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
167
106
80
30
18
6
5
4
3
2
2
1
Options
Supplier
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Immunogen Purified recombinant fragment of PAK2 expressed in E. coli.
Clone 3B5
Isotype IgG1
Purification Ascites
Alternative Name PAK2 (PAK2 Antibody Abstract)
Background PAK2, also known as P21 (CDKN1A)-activated kinase 2. The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. PAK2 is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. PAK2 has been shown to interact with SH3KBP1, CDC42 and Abl gene.
Molecular Weight 61 kDa
Gene ID 5062
HGNC 5062
Research Area Cancer, Apoptosis/Necrosis, Tyrosine Kinases, Kinases/Phosphatases
Pathways MAPK Signaling, RTK Signaling, Fc-epsilon Receptor Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, ICC: 1/200 - 1/1000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
Immunocytochemistry (ICC) image for anti-PAK2 antibody (P21-Activated Kinase 2) (ABIN969338) Figure 1: Confocal immunofluorescence analysis of Hela cells using PAK2 mouse mAb (gr...
Immunohistochemistry (IHC) image for anti-PAK2 antibody (P21-Activated Kinase 2) (ABIN969338) Figure 2: Immunohistochemical analysis of paraffin-embedded human lung cancer (left) ...
Western Blotting (WB) image for anti-PAK2 antibody (P21-Activated Kinase 2) (ABIN969338) Figure 3: Western blot analysis using PAK2 mouse mAb against Hela (1), Jurkat (2), A5...
Product cited in: Machuy, Campa, Thieck, Rudel: "c-Abl-binding protein interacts with p21-activated kinase 2 (PAK-2) to regulate PDGF-induced membrane ruffles." in: Journal of molecular biology, Vol. 370, Issue 4, pp. 620-32, 2007 (PubMed).

Chu, Wu, Liao, Pardo, Zhao, Li, Mendenhall, Pali, Shen, Yu, Taylor, Aversa, Molineaux, Payan, Masuda: "A novel role for p21-activated protein kinase 2 in T cell activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 12, pp. 7324-34, 2004 (PubMed).