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Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 alpha (PPARGC1A) antibody

Details for Product No. ABIN969351
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Antigen
Synonyms PPARGC1A, PPARGC1, A830037N07Rik, ENSMUSG00000079510, Gm11133, PGC-1, PGC-1v, Pgc-1alpha, Pgc1, Pgco1, Ppargc1, PGC1, PGC1A, LEM6, PGC-1(alpha), AVPGC-1ALPHA
Reactivity
Human
(70), (27), (22), (18), (14), (14), (13), (1)
Host
Mouse
(44), (29), (6)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(61), (36), (15), (10), (4), (4), (3), (3), (2), (1), (1)
Pubmed 1 reference available
Quantity 100 µL
Options
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Catalog No. ABIN969351
396.00 $
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Immunogen Purified recombinant fragment of human PGC-1alpha expressed in E. coli.
Clone 1G8
Isotype IgG2b
Purification Ascites
Alternative Name PGC-1 alpha
Background Synonyms:
PPARGC1A, LEM6, PGC1, PGC1A, PGC-1v, PPARGC1, PGC-1 (α)
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy mηbolism. This protein interacts with PPARγ, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.
Molecular Weight 91 kDa
Gene ID 10891
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
anti-Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 alpha (PPARGC1A) antibody Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng)
anti-Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 alpha (PPARGC1A) antibody (2) Figure 1: Western blot analysis using PGC-1alpha mAb against human PGC-1alpha (AA: 570-798) recombinant protein. (Expected MW is 70 kDa)
anti-Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 alpha (PPARGC1A) antibody (3) Figure 2: Western blot analysis using PGC-1alpha mAb against HEK293 (1) and PGC-1alpha-hIgGFc transfected HEK293 (2) cell lysate.
Product cited in: Barrès, Osler, Yan et al.: "Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density." in: Cell metabolism, Vol. 10, Issue 3, pp. 189-98, 2009 (PubMed).

Validation Images
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