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SMAD6 antibody

SMAD6 Reactivity: Human WB, ELISA Host: Mouse Monoclonal 5H3 unconjugated
Catalog No. ABIN969405
  • Target See all SMAD6 Antibodies
    SMAD6 (SMAD, Mothers Against DPP Homolog 6 (SMAD6))
    Reactivity
    • 51
    • 28
    • 12
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    Human
    Host
    • 54
    • 13
    Mouse
    Clonality
    • 56
    • 11
    Monoclonal
    Conjugate
    • 40
    • 5
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SMAD6 antibody is un-conjugated
    Application
    • 58
    • 38
    • 15
    • 12
    • 6
    • 3
    • 3
    • 2
    Western Blotting (WB), ELISA
    Purification
    purified
    Immunogen
    Purified recombinant fragment of human SMAD6 expressed in E. coli. ,
    Clone
    5H3
    Isotype
    IgG1
    Top Product
    Discover our top product SMAD6 Primary Antibody
  • Application Notes
    ELISA: 1:10000, WB: 1:500 - 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    4°C, -20°C for long term storage
  • Shintani, Yagi, Nakayama, Saji, Matsuoka: "A new nonsense mutation of SMAD8 associated with pulmonary arterial hypertension." in: Journal of medical genetics, Vol. 46, Issue 5, pp. 331-7, (2009) (PubMed).

    Shen, Chen, Wang, Kaneki, Xing, Okeefe, Chen: "Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation." in: The Journal of biological chemistry, Vol. 281, Issue 6, pp. 3569-76, (2006) (PubMed).

    Choi, Lee, Lim, Choi, Lee, Lee, Hong, Kim, Kim, Park: "Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1." in: Nature immunology, Vol. 7, Issue 10, pp. 1057-65, (2006) (PubMed).

  • Target
    SMAD6 (SMAD, Mothers Against DPP Homolog 6 (SMAD6))
    Alternative Name
    SMAD6 (SMAD6 Products)
    Synonyms
    madh6 antibody, madh7 antibody, Xsmad6 antibody, hst17432 antibody, AOVD2 antibody, HsT17432 antibody, MADH6 antibody, MADH7 antibody, Madh6 antibody, b2b390Clo antibody, Smad6-like antibody, smad6 antibody, wu:fb22g05 antibody, SMAD family member 6 antibody, SMAD family member 6a antibody, smad6 antibody, SMAD6 antibody, Smad6 antibody, smad6a antibody
    Background

    Description: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members, has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions.Tissue specificity: Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.

    Aliases: MADH6, MADH7, HsT17432, SMAD6

    Molecular Weight
    53 kDa
    Gene ID
    4091
    HGNC
    4091
    Pathways
    Chromatin Binding
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