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SRY (Sex Determining Region Y)-Box 2 (SOX2) (AA 1-170) antibody

Antigen

SRY (Sex Determining Region Y)-Box 2 (SOX2)
Synonyms ANOP3, MCOPS3, MGC2413, RGD1565646, SOX2, MGC148683, lcc, ysb, Sox-2
Binding Site
Alternatives

AA 1-170
Clonality Monoclonal (10F10C9)
Host
Alternatives

Mouse
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives ELISA, Western Blotting (WB)
2 references available
Catalog no. ABIN969413
Quantity 0.1ml  (Variants)
Price 319.00 $   Plus shipping costs $45.00
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Additional Information
Application Details Publications Alternatives Variants back to top

Alternative name SOX2
Gene ID 6657
Immunogen Purified recombinant fragment of SOX2 (AA 1-170) expressed in E. Coli.
Format Liquid
Isotype IgG1
Clone 10F10C9
Description SOX2: SRY (sex determining region Y)-box 2. Entrez Protein NP_003097. It is a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).
Synonyms: ANOP3, MCOPS3, MGC2413
Molecular Weight 34.3kDa

Application Details
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Application Notes Western Blotting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Purification Ascites
Buffer Ascitic fluid containing 0.03% sodium azide.
Preservative 0.03% sodium azide
Storage Store at 4℃, for long term storage, store at -20℃.
Research Area Embryogenesis, Embryonic stem cells, Reproduction, Transcription Factors, Neural Stem Cell marker
Restrictions For Research Use only

Publications
Application Details Alternatives Variants back to top

Product Baer, Eriksson, Faull et al.: "Sox-2 is expressed by glial and progenitor cells and Pax-6 is expressed by neuroblasts in the human subventricular zone." in: Experimental neurology, Vol. 204, Issue 2, pp. 828-31, 2007 (PubMed).

Park, Zhao, West et al.: "Reprogramming of human somatic cells to pluripotency with defined factors." in: Nature, Vol. 451, Issue 7175, pp. 141-6, 2008 (PubMed).

Alternatives
Application Details Publications Variants back to top

Alternatives for antigen "SRY (Sex Determining Region Y)-Box 2 (SOX2)", type "Antibodies"
Hosts Rabbit (87), Mouse (18), Goat (4)
Reactivities Human (103), Mouse (Murine) (35), Rat (Rattus) (30), Dog (Canine) (23), Cow (Bovine) (22), Pig (Porcine) (22), Chicken (21), Sheep (Ovine) (20), Guinea Pig (18), Zebrafish (2), Chimpanzee (1), Xenopus laevis (1)
Applications Western Blotting (WB) (74), ELISA (56), Immunofluorescence (IF) (31), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (21), Immunohistochemistry (IHC) (14), Dot Blot (Dot) (6), Flow Cytometry (FACS) (6), Immunocytochemistry (ICC) (5), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunoprecipitation (IP) (3), Immunoelectron Microscopy (IEM) (1)
Conjugates Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)
Epitopes N-Term (16), C-Term (4), AA 50-100 (2), Ala30 (2), Center (2), Cys265 (2), Internal Region (2), AA 1-170 (1), AA 100-150 (1), AA 76-80 (1), C-Term, AA 240-260 (1), pSer246 (1), pSer249 (1), pSer250 (1), pSer251 (1), pSer83 (1), pTyr108 (1)