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MTDH antibody

MTDH Reactivity: Human WB, IHC, ELISA, FACS Host: Mouse Monoclonal 2F11C3 unconjugated
Catalog No. ABIN969496
  • Target See all MTDH Antibodies
    MTDH (Metadherin (MTDH))
    Reactivity
    • 53
    • 18
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 44
    • 7
    • 3
    Mouse
    Clonality
    • 46
    • 8
    Monoclonal
    Conjugate
    • 32
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MTDH antibody is un-conjugated
    Application
    • 44
    • 14
    • 13
    • 13
    • 12
    • 10
    • 9
    • 9
    • 9
    • 6
    • 5
    • 2
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)
    Purification
    purified
    Immunogen
    Purified recombinant fragment of human Metadherin expressed in E. coli.
    Clone
    2F11C3
    Isotype
    IgG1
    Top Product
    Discover our top product MTDH Primary Antibody
  • Application Notes
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, FCM: 1:200 - 1:400
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Antibody are purified by protein G affinity chromatography. Liquid in PBS containing 50 % glycerol and 0.03 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    4°C, -20°C for long term storage
  • Britt, Yang, Yang, Flanagan, Callanan, Lim, Lin, Hixson: "Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells." in: Experimental cell research, Vol. 300, Issue 1, pp. 134-48, (2004) (PubMed).

    Brown, Ruoslahti: "Metadherin, a cell surface protein in breast tumors that mediates lung metastasis." in: Cancer cell, Vol. 5, Issue 4, pp. 365-74, (2004) (PubMed).

  • Target
    MTDH (Metadherin (MTDH))
    Alternative Name
    Metadherin (MTDH Products)
    Synonyms
    MGC75963 antibody, 2610103J23Rik antibody, 3D3 antibody, 3D3/Lyric antibody, AEG-1 antibody, AV353288 antibody, D8Bwg1112e antibody, Lyric antibody, AEG1 antibody, LYRIC antibody, LYRIC/3D3 antibody, metadherin antibody, mtdh antibody, MTDH antibody, Mtdh antibody
    Background

    Description: Metadherin (Metastasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain, blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.

    Aliases: 3D3, AEG1, LYRIC, MTDH

    Molecular Weight
    64 kDa
    Gene ID
    92140
    HGNC
    92140
    Pathways
    Cellular Response to Molecule of Bacterial Origin, Cell-Cell Junction Organization
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