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ALPL antibody

ALPL Reactivity: Human WB, ELISA, IHC, FACS Host: Mouse Monoclonal 2F4 unconjugated
Catalog No. ABIN969500
  • Target See all ALPL Antibodies
    ALPL (Alkaline Phosphatase, Liver/bone/kidney (ALPL))
    Reactivity
    • 85
    • 50
    • 17
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 83
    • 18
    • 1
    • 1
    Mouse
    Clonality
    • 83
    • 20
    Monoclonal
    Conjugate
    • 61
    • 10
    • 7
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ALPL antibody is un-conjugated
    Application
    • 75
    • 42
    • 26
    • 18
    • 13
    • 13
    • 13
    • 11
    • 11
    • 8
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)
    Purification
    purified
    Immunogen
    Purified recombinant fragment of human ALPL expressed in E. coli.
    Clone
    2F4
    Isotype
    IgG1
    Top Product
    Discover our top product ALPL Primary Antibody
  • Application Notes
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, FCM: 1:200 - 1:400
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified antibody in PBS with 0.05 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    4°C, -20°C for long term storage
  • Kannampuzha, Tupy, Pritzker: "Mercaptopyruvate inhibits tissue-nonspecific alkaline phosphatase and calcium pyrophosphate dihydrate crystal dissolution." in: The Journal of rheumatology, Vol. 36, Issue 12, pp. 2758-65, (2009) (PubMed).

    Kanazawa, Yamaguchi, Yamamoto, Yamauchi, Yano, Sugimoto: "Serum osteocalcin/bone-specific alkaline phosphatase ratio is a predictor for the presence of vertebral fractures in men with type 2 diabetes." in: Calcified tissue international, Vol. 85, Issue 3, pp. 228-34, (2009) (PubMed).

  • Target
    ALPL (Alkaline Phosphatase, Liver/bone/kidney (ALPL))
    Alternative Name
    ALPL (ALPL Products)
    Synonyms
    ALP antibody, iap antibody, alpl antibody, AP-TNAP antibody, APTNAP antibody, HOPS antibody, TNAP antibody, TNSALP antibody, Akp-2 antibody, Akp2 antibody, PHOA antibody, TNS-AP antibody, alkaline phosphatase, liver/bone/kidney L homeolog antibody, alkaline phosphatase, liver/bone/kidney antibody, alkaline phosphatase, intestinal, gene 2 antibody, alkaline phosphatase, liver/bone/kidney pseudogene antibody, alpl.L antibody, ALPL antibody, alpi.2 antibody, LOC100031702 antibody, Alpl antibody
    Background

    Description: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization, however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described.

    Aliases: HOPS, TNAP, APTNAP, TNSALP, AP-TNAP

    Molecular Weight
    57.3 kDa
    Gene ID
    249
    HGNC
    249
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