LPA antibody (AA 4330-4521)

Catalog No. ABIN969533

Product Details anti-LPA Antibody

Target: LPA (APOA) (Apolipoprotein A (APOA))

Binding Specificity: AA 4330-4521

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This LPA antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Purification: purified

Immunogen: Purified recombinant fragment of human LPA (AA: 4330-4521) expressed in E. coli. ,

Clone: 4H1

Isotype: IgG1

Application Details

Application Notes: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

References for anti-LPA antibody (ABIN969533)

Nicholls, Tang, Scoffone, Brennan, Hartiala, Allayee, Hazen: "Lipoprotein(a) levels and long-term cardiovascular risk in the contemporary era of statin therapy." in: Journal of lipid research, Vol. 51, Issue 10, pp. 3055-61, (2010) (PubMed).

Rodger, Le Gal, Carrier, Betancourt, Kahn, Wells, Anderson, Lacut, Chagnon, Solymoss, Crowther, Perrier, White, Vickars, Ramsay, Kovacs: "Serum lipoprotein (a) levels in patients with first unprovoked venous thromboembolism is not associated with subsequent risk of recurrent VTE." in: Thrombosis research, Vol. 126, Issue 3, pp. 222-6, (2010) (PubMed).

Target Details for LPA

Target: LPA (APOA) (Apolipoprotein A (APOA))

Alternative Name: LPA (APOA Products)

Synonyms: AK38 antibody, APOA antibody, LP antibody, Apo(a) antibody, Lp(a) antibody, lipoprotein(a) antibody, LPA antibody

Background:

Description: The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence.

Aliases: LP, AK38, APOA

Molecular Weight: 501 kDa

Gene ID: 4018

HGNC: 4018