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PPM1A antibody (AA 202-382)

PPM1A Reactivity: Human, Monkey WB, ELISA, FACS Host: Mouse Monoclonal 7F12 unconjugated
Catalog No. ABIN969556
  • Target See all PPM1A Antibodies
    PPM1A (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A))
    Binding Specificity
    • 8
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 202-382
    Reactivity
    • 37
    • 19
    • 16
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Monkey
    Host
    • 28
    • 9
    Mouse
    Clonality
    • 29
    • 8
    Monoclonal
    Conjugate
    • 25
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PPM1A antibody is un-conjugated
    Application
    • 30
    • 17
    • 8
    • 5
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Flow Cytometry (FACS)
    Purification
    purified
    Immunogen
    Purified recombinant fragment of human PPM1A (AA: 202-382) expressed in E. coli. ,
    Clone
    7F12
    Isotype
    IgG1
    Top Product
    Discover our top product PPM1A Primary Antibody
  • Application Notes
    ELISA: 1:10000, WB: 1:500 - 1:2000, FCM: 1:200 - 1:400
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified antibody in PBS with 0.05 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    4°C, -20°C for long term storage
  • Malki, Uher, Paya-Cano, Binder, Rietschel, Zobel, Mors, Hauser, Henigsberg, Jerman, Souery, Placentino, Ng, Cohen-Woods, Sluyter, Farmer, Aitchison, Craig, Lewis, McGuffin, Schalkwyk: "Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants." in: Biological psychiatry, Vol. 69, Issue 4, pp. 360-5, (2011) (PubMed).

    Sun, Yu, Dotti, Shen, Tan, Savoldo, Pass, Chu, Zhang, Lu, Fu, Lin, Yang: "PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation." in: Cellular signalling, Vol. 21, Issue 1, pp. 95-102, (2008) (PubMed).

  • Target
    PPM1A (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A))
    Alternative Name
    PPM1A (PPM1A Products)
    Synonyms
    PP2C-ALPHA antibody, PP2CA antibody, PP2Calpha antibody, pp2ca1 antibody, ppp1r13b antibody, si:ch211-253p18.1 antibody, wu:fd42g12 antibody, zgc:153820 antibody, 2310003C21Rik antibody, 2900017D14Rik antibody, AI427932 antibody, AU017636 antibody, MMPa-2 antibody, MPPa-1 antibody, Pp2c1 antibody, pp2c-alpha antibody, pp2ca antibody, pp2calpha antibody, pp2ca2 antibody, protein phosphatase, Mg2+/Mn2+ dependent 1A antibody, protein phosphatase, Mg2+/Mn2+ dependent, 1Ab antibody, protein phosphatase 1A, magnesium dependent, alpha isoform antibody, protein phosphatase, Mg2+/Mn2+ dependent, 1A antibody, protein phosphatase, Mg2+/Mn2+ dependent 1A L homeolog antibody, protein phosphatase, Mg2+/Mn2+ dependent, 1Aa antibody, PPM1A antibody, ppm1ab antibody, Ppm1a antibody, ppm1a.L antibody, ppm1aa antibody
    Background

    Description: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

    Aliases: PP2CA, PP2Calpha, PP2C-ALPHA

    Molecular Weight
    42.4 kDa
    Gene ID
    5494
    HGNC
    5494
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