Interleukin 17A (IL17A) antibody

Details for Product No. ABIN969981
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Antigen
Synonyms Il17, IL17A, CTLA8, IL-17, IL-17A, IL17, Ctla-8, Ctla8, CTLA-8, ChIL-17, IL-17F
Reactivity
Human
(198), (110), (32), (4), (1), (1), (1), (1), (1), (1)
Host
Mouse
(129), (98), (52), (14), (3), (3), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(48), (14), (12), (12), (5), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Application
Western Blotting (WB)
(159), (151), (96), (35), (25), (22), (20), (16), (14), (13), (9), (7), (7), (7), (6), (4), (1), (1), (1)
Pubmed 2 references available
Quantity 100 µg
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Catalog No. ABIN969981
249.00 $
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Isotype IgG2a
Characteristics This is a mouse monoclonal antibody raised by using full-length human IL-17 protein. It was tested on ELISA and WB
Alternative Name IL17A
Background IL-17 is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
Molecular Weight 17kDa
Gene ID 3605
NCBI Accession NP_002181, NM_002190
UniProt Q16552
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-IL17A antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Background publications Rouvier, Luciani, Mattéi et al.: "CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 150, Issue 12, pp. 5445-56, 1993 (PubMed).

Dodon, Li, Hamaia et al.: "Tax protein of human T-cell leukaemia virus type 1 induces interleukin 17 gene expression in T cells." in: The Journal of general virology, Vol. 85, Issue Pt 7, pp. 1921-32, 2004 (PubMed).

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