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Details for Product No. ABIN970002

Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) antibody

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Antigen
Synonyms STAT6B, STAT6C, D12S1644, IL-4-STAT
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN970002
Quantity 100 µg
Price
249.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Isotype IgG
Characteristics This is a mouse monoclonal antibody raised by using full-length human STAT6 protein. It was tested on ELISA and WB
Alternative Name STAT6
Background STAT6 is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins.
Molecular Weight 94kDa
Gene ID 6778
NCBI Accession NP_003144, NM_003153
UniProt P42226
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-STAT6 antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Background publications Takeda, Tanaka, Shi et al.: "Essential role of Stat6 in IL-4 signalling." in: Nature, Vol. 380, Issue 6575, pp. 627-30, 1996 (PubMed).

Alternatives for antigen "Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6)", type "Antibodies"
Hosts (182), (42), (4)
Reactivities (213), (89), (79), (14), (12), (6), (3)
Applications (173), (68), (59), (58), (38), (30), (16), (10), (9), (4), (3), (1)
Conjugates (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1)
Epitopes (44), (31), (11), (4), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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