Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) antibody

Details for Product No. ABIN970002
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Antigen
Synonyms D12S1644, IL-4-STAT, STAT6B, STAT6C
Reactivity
Human
(230), (98), (89), (14), (12), (8), (3)
Host
Mouse
(200), (42), (3), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (1)
Application
Western Blotting (WB)
(187), (81), (74), (51), (41), (30), (18), (15), (10), (6), (5), (1)
Pubmed 1 reference available
Quantity 100 µg
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Catalog No. ABIN970002
249.00 $
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Isotype IgG
Characteristics This is a mouse monoclonal antibody raised by using full-length human STAT6 protein. It was tested on ELISA and WB
Alternative Name STAT6
Background STAT6 is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins.
Molecular Weight 94kDa
Gene ID 6778
NCBI Accession NP_003144, NM_003153
UniProt P42226
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-STAT6 antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Supplier Images
anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) antibody WB Suggested Anti-STAT6 Antibody Titration: 1.0ug/ml
Positive Control: ACHN cell lysate
Background publications Takeda, Tanaka, Shi et al.: "Essential role of Stat6 in IL-4 signalling." in: Nature, Vol. 380, Issue 6575, pp. 627-30, 1996 (PubMed).

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