Tumor Protein P53 (TP53) antibody

Antigen: Tumor Protein P53 (TP53)

Synonyms: p53, LFS1, TRP53, FLJ92943, P53, Trp53, MGC112612, brp53, drp53, fb40d06, wu:fb40d06, zgc:111919, TP53, bbl, bfy, bhy, p44, Tp53, tp53

Clonality: Monoclonal

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: Chromatin Immunoprecipitation (ChiP)

Catalog no.: ABIN970009

Additional Information

Alternative name: TP53

Gene ID: TP53

Format: Lyophilized

Reconstitution: Add distilled water.

Isotype: IgG

Description: Tumor protein p53 responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome

Characteristics: Antigen Size: 393 amino acids

Molecular Weight: 53kDa

Application Details

Application Notes: WB Suggested Anti-TP53 Antibody Titration: 1.0ug/ml
Positive Control: Daudi cell lysate.

Buffer: PBS

Storage (Long Term): For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.

Storage (Short Term): Any unfrozen and/or unused material can be stored at 4°C for short term use (< 1 week), and should not be re-frozen.

Restrictions: For Research Use only

Images

WB Suggested Anti-TP53 Antibody Titration: 1.0ug/ml
Positive Control: Daudi cell lysate

anti-Tumor Protein P53 (TP53) antibody (Image 2)

Publications

Product: Khanna, Keating, Kozlov et al.: "ATM associates with and phosphorylates p53: mapping the region of interaction." in: Nature genetics, Vol. 20, Issue 4, pp. 398-400, 1998 (PubMed).