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Details for Product No. ABIN970011

Tumor Protein P53 (TP53) antibody

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Antigen
Synonyms BCC7, LFS1, P53, TRP53, p53, Trp53, bbl, bfy, bhy, p44, Tp53, Xp53, brp53, drp53, etID22686.5, fb40d06, wu:fb40d06, zgc:111919, tp53
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Chromatin Immunoprecipitation (ChIP)
Pubmed 1 reference available
Catalog no. ABIN970011
Quantity 100 µg
Price
249.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Isotype IgG
Characteristics This is a mouse monoclonal antibody raised by using full-length human p53 wild-type protein. Immunogen was expressed, purified and properly refolded as active tetramer prior to immunization. It was tested on ELISA and WB.
Alternative Name TP53
Background Tumor protein p53 responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome
Molecular Weight 53kDa
Gene ID 7157
NCBI Accession NP_000537, NM_000546
UniProt P04637
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-TP53 antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Background publications Khanna, Keating, Kozlov et al.: "ATM associates with and phosphorylates p53: mapping the region of interaction." in: Nature genetics, Vol. 20, Issue 4, pp. 398-400, 1998 (PubMed).

Alternatives for antigen "Tumor Protein P53 (TP53)", type "Antibodies"
Hosts (860), (429), (5), (3), (2), (2), (1)
Reactivities (1211), (289), (227), (86), (80), (67), (32), (25), (16), (11), (8), (8), (8), (7), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1)
Applications (944), (435), (373), (265), (263), (193), (150), (143), (90), (77), (22), (16), (9), (6), (6), (6), (5), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1)
Conjugates (36), (28), (18), (15), (15), (15), (15), (15), (15), (15), (15), (4), (3), (3), (2), (1), (1)
Epitopes (49), (42), (40), (39), (38), (37), (35), (35), (33), (33), (30), (30), (26), (21), (17), (17), (15), (9), (8), (7), (6), (6), (6), (6), (5), (5), (5), (5), (5), (5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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