Tumor Protein P53 (TP53) antibody

Details for Product No. ABIN970011
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Antigen
Synonyms tp53, p53, TP53, Tp53, bbl, bfy, bhy, p44, TpMs, BCC7, LFS1, P53, TRP53, Trp53, Xp53, brp53, drp53, etID22686.5, fb40d06, wu:fb40d06, zgc:111919
Reactivity
Human
(1376), (313), (266), (77), (76), (66), (49), (24), (15), (12), (9), (8), (6), (5), (5), (5), (4), (3), (2), (2), (2), (1)
Host
Mouse
(1035), (427), (7), (5), (3), (2), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(36), (31), (22), (16), (16), (16), (16), (16), (16), (16), (16), (16), (11), (11), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Chromatin Immunoprecipitation (ChIP)
(1104), (495), (372), (344), (268), (236), (160), (150), (110), (105), (22), (22), (13), (7), (5), (4), (3), (3), (2), (2), (2), (1), (1), (1)
Pubmed 1 reference available
Quantity 100 μg
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Catalog No. ABIN970011
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Isotype IgG
Characteristics This is a mouse monoclonal antibody raised by using full-length human p53 wild-type protein. Immunogen was expressed, purified and properly refolded as active tetramer prior to immunization. It was tested on ELISA and WB.
Alternative Name TP53
Background Tumor protein p53 responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome
Molecular Weight 53kDa
Gene ID 7157
NCBI Accession NM_000546, NP_000537
UniProt P04637
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-TP53 antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Supplier Images
anti-Tumor Protein P53 (TP53) antibody WB Suggested Anti-TP53 Antibody Titration: 0.2ug/ml
Positive Control: Daudi cell lysate
anti-Tumor Protein P53 (TP53) antibody (2) anti-Tumor Protein P53 (TP53) antibody (Image 2)
Background publications Khanna, Keating, Kozlov et al.: "ATM associates with and phosphorylates p53: mapping the region of interaction." in: Nature genetics, Vol. 20, Issue 4, pp. 398-400, 1998 (PubMed).

Validation Images
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