ITM2C antibody (Middle Region)
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- Target See all ITM2C Antibodies
- ITM2C (Integral Membrane Protein 2C (ITM2C))
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Binding Specificity
- Middle Region
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Reactivity
- Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Sheep, Rabbit, Zebrafish (Danio rerio)
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This ITM2C antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- EDSLSSQVRT QMELEEDVKI YLDENYERIN VPVPQFGGGD PADIIHDFQR
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Sheep: 100%, Zebrafish: 91%
- Characteristics
- This is a rabbit polyclonal antibody against ITM2C. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product ITM2C Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 267 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- ITM2C (Integral Membrane Protein 2C (ITM2C))
- Alternative Name
- ITM2C (ITM2C Products)
- Synonyms
- 3110038L02Rik antibody, BRI3 antibody, Bricd2c antibody, E25 antibody, E25C antibody, ITM3 antibody, BRICD2C antibody, fj35c02 antibody, itm2c antibody, wu:fj35c02 antibody, zgc:66349 antibody, wu:fj52a04 antibody, zgc:92783 antibody, integral membrane protein 2C antibody, integral membrane protein 2Cb antibody, integral membrane protein 2Ca antibody, Itm2c antibody, ITM2C antibody, itm2cb antibody, itm2ca antibody
- Background
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ITM2C is a negative regulator of beta amyloid peptide production. ITM2C may inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor.ITM2C may play a role in TNF-induced cell death and neuronal differentiation.
Alias Symbols: BRI3, BRICD2C, E25, E25C, ITM3
Protein Interaction Partner: UBC, Dlg4, RYK, BACE1, RNF7, STT3A, MTNR1B, FURIN,
Protein Size: 267 - Molecular Weight
- 30 kDa
- Gene ID
- 81618
- NCBI Accession
- NM_030926, NP_112188
- UniProt
- Q9NQX7
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