14-3-3 eta antibody (N-Term)

Catalog No. ABIN972023

Product Details anti-14-3-3 eta Antibody

Target: 14-3-3 eta (YWHAH)

Binding Specificity: N-Term

Reactivity: Human, Rabbit, Dog, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This 14-3-3 eta antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: ADGNEKKLEK VKAYREKIEK ELETVCNDVL SLLDKFLIKN CNDFQYESKV

Predicted Reactivity: Dog: 100%, Human: 100%, Rabbit: 100%, Zebrafish: 78%

Characteristics: This is a rabbit polyclonal antibody against YWHAH. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human YWHAH

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 246 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-14-3-3 eta antibody (ABIN972023)

Ubl, Berg, Holzmann, Krüger, Berger, Arzberger, Bornemann, Riess: "14-3-3 protein is a component of Lewy bodies in Parkinson's disease-mutation analysis and association studies of 14-3-3 eta." in: Brain research. Molecular brain research, Vol. 108, Issue 1-2, pp. 33-9, (2002) (PubMed).

Target Details for 14-3-3 eta

Target: 14-3-3 eta (YWHAH)

Alternative Name: YWHAH (YWHAH Products)

Synonyms: ywha1 antibody, 14-3-3e antibody, YWHAH antibody, YWHA1 antibody, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta antibody, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide antibody, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta antibody, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta L homeolog antibody, YWHAH antibody, ywhah antibody, Ywhah antibody, ywhah.L antibody

Background: The YWHAH gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99 % identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat has been associated with early-onset schizophrenia.This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99 % identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat has been associated with early-onset schizophrenia. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: YWHA1
Protein Interaction Partner: DTL, HUWE1, ABL1, SIK3, SUMO2, IRS4, CBL, UBC, UBFD1, EIF5, TBCB, CAPNS1, ALDH7A1, UBE2R2, ISOC1, FERMT2, YWHAQ, PDIA4, YWHAZ, YWHAG, YWHAE, XPO1, VCL, SNRPD2, PCYT2, PTMA, PAK2, PAFAH1B1, MYO1E, HNRNPK, HMGB3, GSS, GNAI3, G6PD, PPP1CA, MARK3, LRRK2, SAV1
Protein Size: 246

Molecular Weight: 28 kDa

Gene ID: 7533

NCBI Accession: NM_003405, NP_003396

UniProt: Q04917

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, C21-Steroid Hormone Metabolic Process, Myometrial Relaxation and Contraction